Evidence map›Paper›PMID 29263806›Full record

ArticleNPJ genomic medicine2016

Genomic medicine in the military.

Mauricio De Castro, Leslie G Biesecker, Clesson Turner, Ruth Brenner, Catherine Witkop, Maxwell Mehlman, Chris Bradburne, Robert C Green

Registry-linked trialOpen access · goldAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ genomic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03276637 (The MilSeq Project), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03276637 nacompletednot on this mapstarted 2017, after this paper: background citation

The MilSeq Project: Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force

TypeinterventionalSponsorBrigham and Women's HospitalRan2017 to 2020Enrolled105ConditionsHealthy Adults, Genetic Predisposition to DiseaseArmsWhole exome sequencing
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Airmen and health-care providers' attitudes toward the use of genomic sequencing in the US Air Force: findings from the MilSeq Project.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
    Article
  8. Genetic testing strategies in the newborn.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Mauricio De CastroUnited States Air Force Medical Genetics Center, 81st Medical Group, Keesler AFB, Biloxi, MS, USA.
Leslie G BieseckerNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Clesson TurnerWalter Reed National Medical Center, Division of Genetics, Department of Pediatrics, United States Army, Bethesda, MD, USA.
Ruth BrennerAir Force Medical Support Agency, Defense Health Headquarters, Falls Church, VA, USA.
Catherine WitkopAir Force Medical Support Agency, Defense Health Headquarters, Falls Church, VA, USA.
Maxwell MehlmanLaw-Medicine center, Case Western Reserve University School of Law, Cleveland, OH, USA.
Chris BradburneNational Security Systems Biology Center, Asymmetric Operations Sector, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
Robert C GreenDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Partners Personalized Medicine, Broad Institute and Harvard Medical School, Boston, MA, USA.
Defense Health Agency · USBroad Institute · USJohns Hopkins University Applied Physics Laboratory · USKeesler Medical Center · USNational Human Genome Research Institute · USUniversity School · USWalter Reed National Military Medical Center · US

Funding

Resource ProjectU41HG006834 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARTIN, CHRISTA LESE, REHM, HEIDI L · 2013 to 2020
$26.9M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Integration of Whole Genome Sequencing into Clinical MedicineU01HG006500 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C. · 2012 to 2016
$11.5M
Genome Sequence-Based Screening for Childhood Risk and Newborn IllnessU19HD077671 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BEGGS, ALAN H., GREEN, ROBERT C. · 2013 to 2018
$6.1M
Impact of Direct to Consumer Genetic TestingR01HG005092 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI GREEN, ROBERT C., ROBERTS, SCOTT · 2010 to 2012
$1.1M
NHGRI NIH HHS R01 HG005092NHGRI NIH HHS U01 HG006500NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U41 HG006834NICHD NIH HHS U19 HD077671
6 · The paper itself

Abstract

The announcement of the Precision Medicine Initiative was an important step towards establishing the use of genomic information as part of the wider practice of medicine. The US military has been exploring the role that genomic information will have in health care for service members (SMs) and its integration into the continuum of military medicine. An important part of the process is establishing robust protections to protect SMs from genetic discrimination in the era of exome/genome sequencing.

Identifiers

PMID29263806
PMCPMC5685294
OpenAlexW2235862316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.