ReviewClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Non-unions.
Review in Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05231148 (Hardware Preservation in Management of Infected Non United or Delayed United Fractures of Long or Short Bones by Debridement and Local Calcium Sulfate Loaded by Antibiotics), which is not on this map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hardware Preservation in Management of Infected Non United or Delayed United Fractures of Long or Short Bones by Debridement and Local Calcium Sulfate Loaded by Antibiotics
Who cites it
49 citing papers in PubMed, 95 citations in OpenAlex.
- Angiogenic and Osteogenic Strategies for Skeletal Regeneration in Aging.Current osteoporosis reports · 2026Review
- The impact of conversion arthroplasty for failed femoral neck or intertrochanteric fractures on complication and mortality rates: A "second-hit" effect?Journal of the Chinese Medical Association : JCMA · 2026Article
- Fibroblast-Derived ECM as a Donor-Specific Pro-Osteogenic Coating Surpassing ASC- and Osteoblast-Derived ECM.Journal of functional biomaterials · 2026Article
- Management of Fracture Non-union in Children: A Literature Review With Two Case Studies.Cureus · 2025Article
- Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- BioBone - A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed fracture healing - study design.Journal of orthopaedic surgery and research · 2025Article
- Custom-Made 3D-Printed Titanium Implants for Managing Segmental Distal Tibial Bone Defects: A Systematic Literature Review.Journal of clinical medicine · 2025Review
- Higher nonunion rates with locking plates compared to dynamic compression plates in forearm diaphyseal fractures: a multicenter study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Failure Modes in Orthopedic Oncologic Reconstructive Surgery: A Review of Imaging Findings and Failure Rates.Current oncology (Toronto, Ont.) · 2024Review
- Analysis of risk factors and development of a nomogram-based prediction model for defective bony non-union.Heliyon · 2024Article
- Antibiotic-Coated Intramedullary Nailing Managing Long Bone Infected Non-Unions: A Meta-Analysis of Comparative Studies.Antibiotics (Basel, Switzerland) · 2024Review
- Promoting bone callus formation by taking advantage of the time-dependent fracture gap strain modulation.Frontiers in surgery · 2024Review
- Risk factors and healthcare costs associated with long bone fracture non-union: a retrospective US claims database analysis.Journal of orthopaedic surgery and research · 2023Article
- Factors Informing the Development of a Clinical Pathway and Patients' Quality of Life after a Non-Union Fracture of the Lower Limb.Healthcare (Basel, Switzerland) · 2023Article
- Management of aseptic nonunions and severe bone defects: let us get this thing healed!OTA international : the open access journal of orthopaedic trauma · 2023Review
- Traumatic Humeral Shaft Non-union With Ulnar Nerve Transection: An Orthobiologics Success Story.Cureus · 2023Article
- New insights in lower limb reconstruction strategies.Therapeutic advances in musculoskeletal disease · 2023Review
- Proximal ulna non-union: treatment concept and postoperative outcome.International orthopaedics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-union of long bones is a significant consequence of fracture treatment. Bone regeneration is a complex physiological process of bone formation which can be seen during normal fracture healing. An improved understanding of the molecular and cellular events that occur during bone repair and remodelling has led to the development of biologic agents that can augment the biological microenvironment and enhance bone repair. Currently, there are different strategies to augment the impaired or "insufficient" bone-regeneration process, including the "gold standard" autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. A lack of standardized outcome measures for comparison of biologic agents in clinical fracture repair trials, frequent off-label use and a limited understanding of the biological activity of these agents at the bone repair site have limited their efficacy in clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.