ArticleInfection and drug resistance2017
Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt.
Article in Infection and drug resistance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Chlorpromazine inhibits the plasmid-mediated oqxAB multidrug efflux pump in Escherichia coli isolates of Egyptian patients with utis.BMC microbiology · 2025Article
- Prevalence and characterization of quinolone resistance and integrons in clinical Gram-negative isolates from Gaza strip, Palestine.Molecular biology reports · 2024Article
- Prevalence of Aminoglycoside Resistance Genes in Clinical Isolates ofMicroorganisms · 2023Article
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Plasmid-Mediated Fluoroquinolone Resistance inJournal of laboratory physicians · 2022Article
- Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq.Archives of Razi Institute · 2022Article
- Molecular detection of gyrA and mexA genes in Pseudomonas aeruginosa.Molecular biology reports · 2021Article
- Distribution of Extended-Spectrum β-Lactamase (ESBL)-Encoding Genes among Multidrug-Resistant Gram-Negative Pathogens Collected from Three Different Countries.Antibiotics (Basel, Switzerland) · 2021Article
- Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review.Infection and drug resistance · 2021Article
- Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach.Frontiers in microbiology · 2019Review
- Mutations inInfection and drug resistance · 2019Article
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2 authors.
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Abstract
objectivesWe set out to investigate the prevalence, different mechanisms, and clonal relatedness of multidrug resistance (MDR) among third-generation cephalosporin-resistant Gram-negative clinical isolates from Egypt. MATERIALS AND
methodsA total of 118 third-generation cephalosporin-resistant Gram-negative clinical isolates were included in this study. Their antimicrobial susceptibility pattern was determined using Kirby-Bauer disk diffusion method. Efflux pump-mediated resistance was tested by the efflux-pump inhibitor-based microplate assay using chlorpromazine. Detection of different aminoglycoside-, β-lactam-, and quinolone-resistance genes was done using polymerase chain reaction. The genetic diversity of MDR isolates was investigated using random amplification of polymorphic DNA.
resultsMost of the tested isolates exhibited MDR phenotypes (84.75%). The occurrence of efflux pump-mediated resistance in the different MDR species tested was 40%-66%.
conclusionMDR phenotypes are predominant among third-generation cephalosporin-resistant Gram-negative bacteria in Egypt and mediated by different mechanisms, with an increased role of efflux pumps in Enterobacteriaceae.
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