Evidence map›Paper›PMID 29263644›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2017

Thin minimal rim width at Bruch's membrane opening is associated with glaucomatous paracentral visual field loss.

Elise V Taniguchi, Eleftherios I Paschalis, Dejiao Li, Kouros Nouri-Mahdavi, Stacey C Brauner, Scott H Greenstein, Angela V Turalba, Janey L Wiggs, Louis R Pasquale, Lucy Q Shen

Abstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elise V TaniguchiDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Eleftherios I PaschalisDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Dejiao LiDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Kouros Nouri-MahdaviDepartment of Ophthalmology, David Geffen School of Medicine and Stein Eye Institute, Los Angeles, CA, USA.
Stacey C BraunerDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Scott H GreensteinDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Angela V TuralbaDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Janey L WiggsDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Louis R PasqualeDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.
Lucy Q ShenDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA.

Funding

P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Eric A Pierce · 2002 to 2026
$15.1M
The NEIGHBORHOOD: POAG Heritable Overall Operational DatabaseR01EY022305 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI WIGGS, JANEY L · 2012 to 2025
$7.9M
NEI NIH HHS P30 EY014104NEI NIH HHS R01 EY022305
6 · The paper itself

Abstract

purposeTo compare optic nerve head (ONH) measurements in glaucomatous eyes with paracentral visual field (VF) loss to eyes with peripheral VF loss and controls.

methodsOpen-angle glaucoma (OAG) patients with early paracentral VF loss or isolated peripheral VF loss as well as control subjects underwent ONH imaging with swept-source optical coherence tomography (OCT) and retinal nerve fiber layer (RNFL) imaging with spectral-domain OCT. Minimum rim width at Bruch's membrane opening (BMO-MRW), lamina cribrosa depth (LCD), and RNFL thickness were compared among the glaucoma and control groups with one-way analysis of variance, Kruskal-Wallis test, and multiple regression analysis.

resultsTwenty-nine eyes from 29 OAG patients (15 early paracentral and 14 isolated peripheral VF loss) and 20 eyes of 20 control subjects were included. The early paracentral and isolated peripheral VF loss groups had similar VF mean deviation (MD) (-5.3±2.7 dB and -3.7±3.0 dB,

conclusionThin minimal BMO-MRW may represent a new structural biomarker associated with early glaucomatous paracentral VF loss.

Indexed as

BMO-MRWopen angle glaucomaoptic nerve damageparacentral lossswept-source OCT

Identifiers

PMID29263644
PMCPMC5726361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.