ArticleScientific reports2017
Deciphering the emergence, genetic diversity and evolution of classical swine fever virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Emergence of a Candidate Novel Sub-Genotype 1.1d of Classical Swine Fever Virus in India: Insights from a Comprehensive NS5B Gene Analysis and Multi-Locus Phylogeny.Current microbiology · 2026Article
- Multi-laboratory proficiency assessment for molecular and serological diagnosis of classical and African swine fever in the Americas.Frontiers in veterinary science · 2026Article
- Global population dynamics and evolutionary selection in classical swine fever virus complete genomes: insights from Bayesian coalescent analysis.Virus genes · 2025Article
- Article
- Temporal and coevolutionary analyses reveal the events driving the emergence and circulation of human mamastroviruses.Emerging microbes & infections · 2023Article
- Cross-reactivities and cross-neutralization of different envelope glycoproteins E2 antibodies against different genotypes of classical swine fever virus.Frontiers in veterinary science · 2023Article
- Molecular Epidemiology Questions Transmission Pathways Identified During the Year 2000 Outbreak of Classical Swine Fever in the UK.Frontiers in microbiology · 2022Article
- The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe.Virus evolution · 2022Article
- The Diversity and Spatiotemporally Evolutionary Dynamic of Atypical Porcine Pestivirus in China.Frontiers in microbiology · 2022Article
- Article
- Comparative Analysis of Tunisian Sheep-like Virus, Bungowannah Virus and Border Disease Virus Infection in the Porcine Host.Viruses · 2021Article
- Phylogenetic analysis of classical swine fever virus isolates from China.Archives of virology · 2021Article
- Article
- The Novel Genetic Background of Infectious Bursal Disease Virus Strains Emerging from the Action of Positive Selection.Viruses · 2021Article
- A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions.Vaccines · 2021Review
- Advanced Research in Porcine Reproductive and Respiratory Syndrome Virus Co-infection With Other Pathogens in Swine.Frontiers in veterinary science · 2021Review
- Unraveling the Global Phylodynamic and Phylogeographic Expansion ofPathogens (Basel, Switzerland) · 2020Article
- Article
- Foetal Immune Response Activation and High Replication Rate during Generation of Classical Swine Fever Congenital Infection.Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical swine fever (CSF) is one of the most important infectious diseases causing significant economic losses. Its causal agent, CSF virus (CSFV), is a member of the Pestivirus genus included into the Flaviviridae family. Previous molecular epidemiology studies have revealed the CSFV diversity is divided into three main genotypes and different subgenotypes. However, the classification system for CSFV has not yet been harmonized internationally. Similarly, the phylogeny and evolutionary dynamics of CSFV remain unclear. The current study provides novel and significant insights into the origin, diversification and evolutionary process of CSFV. In addition, the best phylogenetic marker for CSFV capable of reproducing the same phylogenetic and evolutionary information as the complete viral genome is characterized. Also, a reliable cut-off to accurately classify CSFV at genotype and subgenotype levels is established. Based on the time for the most recent common ancestor (tMRCA) reconstruction and cophylogenetic analysis, it was determined that CSFV emerged around 225 years ago when the Tunisian Sheep Virus jumped from its natural host to swine. CSFV emergence was followed by a genetic expansion in three main lineages, driven by the action of positive selection pressure and functional divergence, as main natural forces.
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