Evidence map›Paper›PMID 29263272›Full record

ArticleJournal of virology2018

RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.

Thinesshwary Yogarajah, Kien Chai Ong, David Perera, Kum Thong Wong

Abstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thinesshwary YogarajahDepartment of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0002-6894-1478
Kien Chai OngDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
David PereraInstitute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Kum Thong WongDepartment of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia wongkt@ummc.edu.my.
University of Malaya · MYUniversiti Malaysia Sarawak · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) are closely related enteroviruses that cause the same hand, foot, and mouth disease (HFMD), but neurological complications occur only very rarely in CV-A16 compared to EV-A71 infections. To elucidate host responses that may be able to explain these differences, we performed transcriptomic analysis and real-time quantitative PCR (RT-qPCR) in CV-A16-infected neuroblastoma cells (SK-N-SH), and the results showed that the radical

Indexed as

5' Untranslated RegionsCell Line, TumorDNA-Binding ProteinsEnterovirus A, HumanEnterovirus C, HumanGene Knockdown TechniquesHumansNeuronsOxidoreductases Acting on CH-CH Group DonorsProteinsViperin ProteinVirus Replication5' Untranslated RegionsAIM2 protein, humanDNA-Binding ProteinsOxidoreductases Acting on CH-CH Group DonorsProteinsRSAD2 protein, humanViperin Protein5′ nontranslated regionAIM2coxsackievirus A16enterovirus 71RSAD2SK-N-SH

Identifiers

PMID29263272
PMCPMC5827383
OpenAlexW2778820258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.