ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Selective Suppression of Local Interneuron Circuits in Human Motor Cortex Contributes to Movement Preparation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04807764 (Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
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- Wearable Wireless EMG Sensors for Monitoring Post-Error Neuromuscular Responses During a Sport-Specific Inhibitory Control Task.Biosensors · 2026Article
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- Muscle bursting and corticomotor excitability mark impaired impulse control in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Motor cortical excitability and inhibition are differentially modulated by aerobic exercise intensity.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Corticospinal excitability during timed interception depends on the speed of the moving target.Journal of neurophysiology · 2025Article
- On the Relation Between the Interstimulus Intervals and Multi-Muscle nTMS Motor Mapping.Brain topography · 2025Article
- Corticospinal excitability at rest outside of a task does not differ from task intertrial intervals in healthy adults.Experimental brain research · 2024Article
- Real-time cortical dynamics during motor inhibition.Scientific reports · 2024Article
- Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system.The Journal of physiology · 2023Review
- Influence of coil orientation on corticospinal excitability of trunk muscles during postural and volitional tasks in healthy adults.Frontiers in human neuroscience · 2023Article
- The recruitment of indirect waves within primary motor cortex during motor imagery: A directional transcranial magnetic stimulation study.The European journal of neuroscience · 2022Article
- Intracortical facilitation and inhibition in human primary motor cortex during motor skill acquisition.Experimental brain research · 2022Article
- The Effect of Coil Orientation on the Stimulation of the Pre-Supplementary Motor Area: A Combined TMS and EEG Study.Brain sciences · 2022Article
- Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson's disease.Journal of neurophysiology · 2022Article
- Action Selection and Motor Decision Making: Insights from Transcranial Magnetic Stimulation.Brain sciences · 2022Review
- Inhibition for gain modulation in the motor system.Experimental brain research · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Changes in neural activity occur in the motor cortex before movement, but the nature and purpose of this preparatory activity is unclear. To investigate this in the human (male and female) brain noninvasively, we used transcranial magnetic stimulation (TMS) to probe the excitability of distinct sets of excitatory inputs to corticospinal neurons during the warning period of various reaction time tasks. Using two separate methods (H-reflex conditioning and directional effects of TMS), we show that a specific set of excitatory inputs to corticospinal neurons are suppressed during motor preparation, while another set of inputs remain unaffected. To probe the behavioral relevance of this suppression, we examined whether the strength of the selective preparatory inhibition in each trial was related to reaction time. Surprisingly, the greater the amount of selective preparatory inhibition, the faster the reaction time was. This suggests that the inhibition of inputs to corticospinal neurons is not involved in preventing the release of movement but may in fact facilitate rapid reactions. Thus, selective suppression of a specific set of motor cortical neurons may be a key aspect of successful movement preparation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.