ArticleThe Journal of experimental medicine2018
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Real-world Investigation of the Combination of Darafenib or Trametinib and Clofarabine in the Treatment of High-risk, Recurrent, or Refractory Pediatric Patients With Langerhans Cell Histiocytosis.
Modified LCH-III Regimen Versus Modified LCH-III Regimen Combined With Luvometinib in the Treatment of Multisystem Pediatric Langerhans Cell Histiocytosis: A Multicenter, Open-Label, Randomized Controlled Clinical Trial
Who cites it
45 citing papers in PubMed, 81 citations in OpenAlex.
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Histiocytosis development and clinical variation through the lens of genomics.The Journal of pathology · 2026Review
- Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real-world study.International journal of cancer · 2026Article
- Blood MMP-7 and TNF-α levels as potential prognostic biomarkers for adult pulmonary Langerhans cell histiocytosis.Scientific reports · 2026Article
- Intact lymph node homing and CD8Frontiers in immunology · 2026Article
- [Chinese expert consensus on the diagnosis and treatment of adult Langerhans cell histiocytosis (2025)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Article
- Targeted Therapy With Vemurafenib in Brazilian Children With Refractory Langerhans Cell Histiocytosis: Two Case Reports and Review of Literature.Cancer reports (Hoboken, N.J.) · 2024Review
- Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures.Cancer · 2024Review
- Pathologic characteristics of histiocytic and dendritic cell neoplasms.Blood research · 2024Review
- Clofarabine monotherapy in aggressive, relapsed and refractory Langerhans cell histiocytosis.British journal of haematology · 2024Article
- Clinical, radiological and molecular responses to combination chemotherapy with MAPK pathway inhibition in relapsed and refractory Langerhans cell histiocytosis.British journal of haematology · 2024Article
- Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders.Haematologica · 2024Article
- Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.Immunity · 2023Article
- Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.Hematology. American Society of Hematology. Education Program · 2023Review
- Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling.Clinical and experimental medicine · 2023Article
- Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells.Haematologica · 2023Article
- Children's Oncology Group's 2023 blueprint for research: Non-Hodgkin lymphoma.Pediatric blood & cancer · 2023Article
- Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.Cancer science · 2023Article
- The world of rare interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 5 institutions in 2 countries.
Brandon HogstadDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Marie-Luise BerresDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Rikhia ChakrabortyTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Jun TangTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-8285-5111
Camille BigenwaldDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-2714-2087
Madhavika SerasingheDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Karen Phaik Har LimTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Howard LinTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.ORCID 0000-0002-0847-904X
Tsz-Kwong ManTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Romain RemarkDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Samantha BaxterTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Veronika KanaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Stefan JordanDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Zoi KarouliaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-4973-6604
Wing-Hong KwanDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Marylene LeboeufDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Elisa BrandtDepartment of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany.
Helene SalmonDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Kenneth McClainTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Poulikos PoulikakosDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Jerry ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-1337-842X
Willem J M MulderTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Carl E AllenTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX ceallen@txch.org.
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY miriam.merad@mssm.edu.ORCID 0000-0002-4481-7827
Icahn School of Medicine at Mount Sinai · USBaylor College of Medicine · USImaging Center · USRWTH Aachen University · DEMemorial Sloan Kettering Cancer Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MVaccine Induced Activation of T Follicular Helper Cell SubsetsU19AI089987 · NIAID · BAYLOR RESEARCH INSTITUTE · PI PASCUAL, MARIA VIRGINIA · 2010 to 2015
$17.0MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0MNovel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disesaseU24AI118644 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERIN, CECILIA, MERAD, MIRIAM · 2015 to 2020
$2.4MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MHarnessing Csf-2 compartmentalized role on tissue resident phagocytes to uncouple anti-tumoral from pathological immunity induced by checkpoint inhibitorsR01CA190400 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2015 to 2019
$1.9M(PQ5) Role of Mitochondrial Division in Cancer BiologyR01CA206005 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIPUK, JERRY EDWARD · 2016 to 2020
$1.7MHoward Hughes Medical InstituteNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA125123NCI NIH HHS P30 CA196521NCI NIH HHS P50 CA126752NCI NIH HHS R01 CA154489NCI NIH HHS R01 CA154947NCI NIH HHS R01 CA190400NCI NIH HHS R01 CA206005NHLBI NIH HHS F31 HL126484NIAID NIH HHS U19 AI089987NIAID NIH HHS U24 AI118644NIDDK NIH HHS P30 DK020541NIDDK NIH HHS T32 DK060445NIH HHS S10 OD018522
Abstract
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207
Indexed as
AnimalsApoptosisCell MovementDendritic CellsHistiocytosis, Langerhans-CellHumansLangerhans CellsMAP Kinase Signaling SystemMiceMice, Inbred C57BLMutationPhagocytosisProto-Oncogene Proteins B-rafProto-Oncogene Proteins B-raf
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
NCT07022834ClinicalTrials.gov
NCT07431060ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.