Evidence map›Paper›PMID 29263161›Full record

ArticleCancer immunology research2018

ImmunoMap: A Bioinformatics Tool for T-cell Repertoire Analysis.

John-William Sidhom, Catherine A Bessell, Jonathan J Havel, Alyssa Kosmides, Timothy A Chan, Jonathan P Schneck

Abstract read
In one paragraph

Article in Cancer immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Human TCR repertoire in cancer.Cancer medicine · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. NAIR: Network Analysis of Immune Repertoire.Frontiers in immunology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  20. Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John-William SidhomDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Catherine A BessellGraduate Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jonathan J HavelHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Alyssa KosmidesDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Timothy A ChanHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Jonathan P SchneckInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland. jschnec1@jhmi.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Lung Transplant Clinical Trials Network (LT-CTN)U01AI113315 · NIAID · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2014 to 2018
$12.9M
Lung Repair and Regeneration Consortium Administrative Coordinating CenterU01HL110967 · NHLBI · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2012 to 2016
$6.2M
Use of aAPC for Melanoma Adoptive ImmunotherapyR01CA108835 · NCI · JOHNS HOPKINS UNIVERSITY · PI SCHNECK, JONATHAN P · 2004 to 2015
$3.3M
ANTIGEN SPECIFIC MODULATION OF T CELL RESPONSESR01AI044129 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHNECK, JONATHAN P · 1999 to 2009
$3.0M
Translational Research in Oncology Training ProgramT32CA160001 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SAWYERS, CHARLES L. · 2011 to 2020
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA108835NCI NIH HHS T32 CA160001NHLBI NIH HHS U01 HL110967NIAID NIH HHS R01 AI044129NIAID NIH HHS U01 AI113315
6 · The paper itself

Abstract

Despite a dramatic increase in T-cell receptor (TCR) sequencing, few approaches biologically parse the data in a fashion that both helps yield new information about immune responses and may guide immunotherapeutic interventions. To address this issue, we developed a method, ImmunoMap, that utilizes a sequence analysis approach inspired by phylogenetics to examine TCR repertoire relatedness. ImmunoMap analysis of the CD8 T-cell response to self-antigen (K

Indexed as

AnimalsComputational BiologyHumansLymphocyte ActivationMiceMice, Inbred C57BLReceptors, Antigen, T-CellT-LymphocytesReceptors, Antigen, T-Cell

Identifiers

PMID29263161
PMCPMC6478441

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.