Evidence map›Paper›PMID 29263147›Full record

ArticleBioscience reports2018

Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves.

Long Guo, Huibin Tian, Jing Shen, Chen Zheng, Shimin Liu, Yangchun Cao, Chuanjiang Cai, Junhu Yao

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

  1. DNAJC12 Stabilizes Phenylalanine Hydroxylase and Facilitates Its Substrate-Dependent Activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Long GuoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Huibin TianCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Jing ShenCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Chen ZhengCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Shimin LiuUWA School of Agriculture and Environment, The University of Western Australia, Crawley, WA 6009, Australia.
Yangchun CaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Chuanjiang CaiCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Junhu YaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China yaojunhu2004@sohu.com.
Northwest A&F University · CNUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As new nutritional strategies for ruminant are designed to change production efficiency by improving the supply of rumen protect protein, lipid, and even starch, the digestive system must fit to utilize these increased nutrient supplies, especially the pancreas. The objective of this study was to investigate the effects of phenylalanine (Phe) on digestive enzymes synthesis or secretion and cellular signaling in pancreatic acinar (PA) cells of dairy calves. The PA cells isolated from fresh pancreas of dairy calves, and cultured in completed RIPA 1640 medium with no fetal serum but 0, 0.15 and 0.45 mM Phe at 37°C in CO

Indexed as

Acinar Cellsalpha-AmylasesAnimalsCattleEpithelial CellsGene Expression Regulation, EnzymologicLipasePancreasPhenylalaninePhosphorylationPrimary Cell CultureProtein BiosynthesisRibosomal Protein S6 KinasesSignal TransductionTrypsinalpha-AmylasesLipasePhenylalanineRibosomal Protein S6 KinasesTrypsindairy calvesmammalian target of rapamycin (mTOR)pancreasphenylalaninetranslation regulationα-amylase

Identifiers

PMID29263147
PMCPMC5784178
OpenAlexW2777437985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.