Evidence map›Paper›PMID 29263143›Full record

ArticleBioscience reports2018

MicroRNA-638 inhibits cell growth and tubule formation by suppressing VEGFA expression in human Ewing sarcoma cells.

Xin Zhou, Jiajun Chen, Qianren Xiao, Tengyu Wang, Yu Yu, Bo Li, Gaohai Shao, Yunyun Li, Zhongzu Zhang

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Biological Function of MicroRNAs in Bone Tumors.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xin ZhouDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Jiajun ChenDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Qianren XiaoDepartment of Pain Management, the Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi 343000, P.R. China.
Tengyu WangDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Yu YuDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Bo LiDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Gaohai ShaoDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China.
Yunyun LiDepartment of Gynecology and Obstetrics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China zhangzhongzu@126.com zzz2lyy@126.com.
Zhongzu ZhangDepartment of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, P.R. China zhangzhongzu@126.com zzz2lyy@126.com.
Chongqing Medical University · CNJinggangshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ewing sarcoma (EWS) is a kind of aggressive tumor of bone and soft tissues, which most occurring in children and adolescents. MicroRNAs (miRNAs) perform essential function in the progression and development of EWS, while the putative role of miR-638 in EWS remains uncertain. Accordingly, we detected the expression of miR-638 and explored its putative biological effects on the malignant phenotype of EWS cells. As expected, miR-638 was significantly down-regulated in EWS cells. Moreover, overexpression of miR-638 suppressed cell growth, induced cell apoptosis, and inhibited tubule formation of EWS cells

Indexed as

ApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMicroRNAsSarcoma, EwingVascular Endothelial Growth Factor AMicroRNAsMIRN638 microRNA, humanVascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesisEwing SarcomamiR-638VEGFA

Identifiers

PMID29263143
PMCPMC5773810
OpenAlexW2779340774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.