ArticleHospital pediatrics2018
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.
Article in Hospital pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 245 citations in OpenAlex.
- Acupuncture for neonatal abstinence syndrome in newborn infants.The Cochrane database of systematic reviews · 2025Pooled it
- Eat, Sleep, Console model for neonatal opioid withdrawal syndrome: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Opioid treatment for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.The New England journal of medicine · 2023Trial
- Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.Neurotoxicology and teratologyTrial
- Regional Evidence on Neonatal Abstinence Syndrome: Association Between Finnegan Score Severity and Laboratory Findings in a Tertiary NICU.Healthcare (Basel, Switzerland) · 2026Article
- Longitudinal academic achievement in children with a history of neonatal abstinence syndrome: a retrospective observational cohort study.Lancet regional health. Americas · 2026Article
- A Structural Examination of Racial Differences in Pharmacologic Treatment Among Opioid Exposed Infants.Journal of racial and ethnic health disparities · 2026Article
- Therapeutic Update in Neonatal Opioid Withdrawal Syndrome: Comparative Effectiveness of Pharmacological Treatments and the ESC Assessment Model. A Systematic Review.Health science reports · 2026Review
- Modeling heart rate patterns to quantify neonatal opioid withdrawal syndrome.Pediatric research · 2026Article
- Interventions to reduce pharmacologic opioid exposure in neonatal opioid withdrawal syndrome: a systematic review and meta-analysis of randomized studies.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Advances in experimental medicine and biology · 2026Review
- A Roadmap to Improved Quality Outcomes in Neonates Exposed to Illegally Manufactured Fentanyl.Journal of pediatrics. Clinical practice · 2025Article
- A retrospective cohort study of neonatal abstinence syndrome patients following implementation of Eat Sleep Console Protocol.Paediatrics & child health · 2025Article
- La prise en charge des nouveau-nés à risque de syndrome d'abstinence néonatale et de syndrome de sevrage néonatal aux opioïdes : mises à jour et pratiques exemplaires émergentes.Paediatrics & child health · 2025Review
- Managing newborns at risk for neonatal abstinence syndrome (NAS)/neonatal opioid withdrawal syndrome (NOWS): Updates and emerging best practices.Paediatrics & child health · 2025Review
- Defining the Hospitalist Workforce in the Care of Newborns.Hospital pediatrics · 2025Article
- A phase I pilot study of a mobile education tool for supporting pregnant women with opioid use disorder.Drug and alcohol dependence reports · 2025Article
- Systemic barriers and stigma: Healthcare provider perspectives on perinatal and neonatal care in the fentanyl crisis.Journal of substance use and addiction treatment · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNeonatal abstinence syndrome (NAS) is a growing problem and poses a significant burden on the health care system. The traditional Finnegan Neonatal Abstinence Scoring System (FNASS) assessment approach may lead to unnecessary opioid treatment of infants with NAS. We developed a novel assessment approach and describe its effect on the management of infants with NAS.
methodsWe retrospectively compared treatment decisions of 50 consecutive opioid-exposed infants managed on the inpatient unit at the Yale New Haven Children's Hospital. All infants had FNASS scores recorded every 2 to 6 hours but were managed by using the Eat, Sleep, Console (ESC) assessment approach. Actual treatment decisions made by using the ESC approach were compared with predicted treatment decisions based on recorded FNASS scores. The primary outcome was postnatal treatment with morphine.
resultsBy using the ESC approach, 6 infants (12%) were treated with morphine compared with 31 infants (62%) predicted to be treated with morphine by using the FNASS approach (
conclusionsInfants managed by using the ESC approach were treated with morphine significantly less frequently than they would have been by using the FNASS approach. The ESC approach is an effective method for the management of infants with NAS that limits pharmacologic treatment and may lead to substantial reductions in length of stay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.