ArticleInfection and immunity2018
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans.
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Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026Review
- Condensation of cGAS induced by TyrScience signaling · 2026Article
- Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2025Review
- IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bacterial surface lipoproteins mediate epithelial microinvasion byInfection and immunity · 2024Article
- Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.Nature communications · 2024Article
- Function and regulation of cGAS-STING signaling in infectious diseases.Frontiers in immunology · 2023Review
- STING Targeting in Lung Diseases.Cells · 2022Review
- TBK1's Role in Bacterial Pneumonia: Perhaps More than Macrophages and IFNs.American journal of respiratory cell and molecular biology · 2022Article
- TBK1 Is Required for Host Defense Functions Distinct from Type I IFN Expression and Myeloid Cell Recruitment in MurineAmerican journal of respiratory cell and molecular biology · 2022Article
- The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity.Frontiers in immunology · 2021Review
- cGAS-STING and MyD88 Pathways Synergize in Ly6CFrontiers in immunology · 2021Article
- An in vivo atlas of host-pathogen transcriptomes duringProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cytosolic Sensors for Pathogenic Viral and Bacterial Nucleic Acids in Fish.International journal of molecular sciences · 2020Review
- Regulation of cGAS-Mediated Immune Responses and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H.Frontiers in immunology · 2020Article
- The Role of NLRP3 Inflammasome in Pneumococcal Infections.Frontiers in immunology · 2020Review
- Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity.Frontiers in immunology · 2020Review
- Unique Roles forFrontiers in immunology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 3 countries.
Juan Sebastian Ruiz-MorenoDepartment of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Lutz HamannInstitute of Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Lei JinDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, Florida, USA.
Leif E SanderDepartment of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Monika Puzianowska-KuznickaDepartment of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
John CambierDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Martin WitzenrathDepartment of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Ralf R SchumannInstitute of Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Norbert SuttorpDepartment of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bastian OpitzDepartment of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany bastian.opitz@charite.de.
Freie Universität Berlin · DEGerman Center for Lung Research · DEHumboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DEPostgraduate School of Molecular Medicine · PLUniversity of Colorado Denver · USUniversity of Florida · US
Funding
THE REGULATION OF V ALPHA 7 EXPRESSING T CELLSP01AI022295 · NIAID · NATIONAL JEWISH HEALTH · PI REFAELI, YOSEF · 1985 to 2011
$11.7MAutoimmunity risk alleles compromising B cell anergyR01AI124487 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CAMBIER, JOHN C · 2016 to 2020
$2.5MImpact of Human STING Variants on Pneumococcal Vaccine EffectivenessR21AI125999 · NIAID · UNIVERSITY OF FLORIDA · PI JIN, LEI · 2016 to 2017
$413kMouse modeling of a human STING gene variant for infectious diseaseR21AI099346 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CAMBIER, JOHN C · 2012 to 2013
$410kNIAID NIH HHS P01 AI022295NIAID NIH HHS R01 AI124487NIAID NIH HHS R21 AI099346NIAID NIH HHS R21 AI125999
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAnimalsCohort StudiesCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansImmunity, InnateInterferon Type IMacrophagesMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMiddle AgedcGAS protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseInterferon Type IMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSting1 protein, mouseSTING ProteincGAShumaninnate immunitypneumoniasingle-nucleotide polymorphismSTINGStreptococcus pneumoniaetype I interferons
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.