Evidence map›Paper›PMID 29263106›Full record

ArticleInfection and immunity2018

Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice.

Leticia Monin, Shail Mehta, Waleed Elsegeiny, Radha Gopal, Jeremy P McAleer, Tim D Oury, Jay Kolls, Shabaana A Khader

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Exacerbation ofVirulence · 2021
    Article
  6. Review
  7. Allergic Diseases Caused byAntibiotics (Basel, Switzerland) · 2021
    Review
  8. Severe PulmonaryInternational medical case reports journal · 2021
    Article
  9. Interactions betweenJournal of fungi (Basel, Switzerland) · 2019
    Review
  10. Concomitant Presence ofFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Leticia Monin *Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Shail Mehta *Division of Pulmonary and Critical Care Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Waleed ElsegeinyRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1170-4890
Radha GopalRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.
Jeremy P McAleerRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.
Tim D OuryDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jay KollsRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA jkolls1@tulane.edu sakhader@wustl.edu.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA jkolls1@tulane.edu sakhader@wustl.edu.
Children's Hospital of Pittsburgh · USWashington University in St. Louis · USUniversity of Pittsburgh · US

Funding

PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
ROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9M
NHLBI NIH HHS R01 HL105427NHLBI NIH HHS T32 HL007317
6 · The paper itself

Abstract

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and inflammation, which, in turn, cause chronic lung disease and respiratory failure. Recently, rates of nontuberculous mycobacterial (NTM) infections in CF patients have been increasing. Of particular relevance is infection with

Indexed as

AnimalsAspergillosisAspergillus fumigatusCoinfectionCystic FibrosisFemaleHumansInterleukin-17LungMaleMiceMice, Inbred C57BLMycobacterium abscessusMycobacterium Infections, NontuberculousInterleukin-17Aspergilluscystic fibrosiscytokinesnontuberculous mycobacteriumpulmonary immunity

Identifiers

PMID29263106
PMCPMC5820964
OpenAlexW2776180902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.