Evidence map›Paper›PMID 29263094›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria.

Changhan Lee, Kamila B Franke, Shady Mansour Kamal, Hyunhee Kim, Heinrich Lünsdorf, Jasmin Jäger, Manfred Nimtz, Janja Trček, Lothar Jänsch, Bernd Bukau and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Complete genome sequences ofMicrobiology resource announcements · 2026
    Article
  3. ClpB enhances thermotolerance inMicrobiology spectrum · 2025
    Article
  4. Article
  5. TheeLife · 2024
    Article
  6. Article
  7. Cytoplasmic molecular chaperones in Pseudomonas species.Journal of microbiology (Seoul, Korea) · 2022
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Protein aggregation in bacteria.FEMS microbiology reviews · 2020
    Review
  20. Heat and Pressure Resistance inFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Changhan LeeDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17177, Sweden.
Kamila B FrankeCenter for Molecular Biology of the University of Heidelberg (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, 69120, Germany.
Shady Mansour KamalDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17177, Sweden.
Hyunhee KimDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17177, Sweden.
Heinrich LünsdorfCentral Facility for Microscopy, The Helmholtz Centre for Infection Research, Braunschweig, 38124, Germany.
Jasmin JägerCenter for Molecular Biology of the University of Heidelberg (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, 69120, Germany.
Manfred NimtzCellular Proteomics, The Helmholtz Centre for Infection Research, Braunschweig, 38124, Germany.
Janja TrčekFaculty of Natural Sciences and Mathematics, Department of Biology, University of Maribor, Maribor, 2000, Slovenia.
Lothar JänschCellular Proteomics, The Helmholtz Centre for Infection Research, Braunschweig, 38124, Germany.
Bernd BukauCenter for Molecular Biology of the University of Heidelberg (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, 69120, Germany.
Axel MogkCenter for Molecular Biology of the University of Heidelberg (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, 69120, Germany; Ute.Romling@ki.se a.mogk@zmbh.uni-heidelberg.de.ORCID 0000-0003-3674-5410
Ute RömlingDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17177, Sweden; Ute.Romling@ki.se a.mogk@zmbh.uni-heidelberg.de.ORCID 0000-0003-3812-6621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AAA+ disaggregases solubilize aggregated proteins and confer heat tolerance to cells. Their disaggregation activities crucially depend on partner proteins, which target the AAA+ disaggregases to protein aggregates while concurrently stimulating their ATPase activities. Here, we report on two potent ClpG disaggregase homologs acquired through horizontal gene transfer by the species

Indexed as

Adaptation, PhysiologicalHot TemperatureBacterial ProteinsGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicGene Transfer, HorizontalPhylogenyPseudomonas aeruginosaBacterial ProteinsAAA+ proteinheat toleranceHsp100mobile genetic elementprotein disaggregation

Identifiers

PMID29263094
PMCPMC5777039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.