Evidence map›Paper›PMID 29263071›Full record

ArticleAntimicrobial agents and chemotherapy2018

Reversal of Azole Resistance in Candida albicans by Sulfa Antibacterial Drugs.

Hassan E Eldesouky, Abdelrahman Mayhoub, Tony R Hazbun, Mohamed N Seleem

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Overcoming amphotericin B resistance inAntimicrobial agents and chemotherapy · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Atazanavir Resensitizes Candida auris to Azoles.Antimicrobial agents and chemotherapy · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Frontiers in cellular and infection microbiology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Antifungal Drug Repurposing.Antibiotics (Basel, Switzerland) · 2020
    Article
  20. Genome-Scale Metabolic Model of the Human PathogenJournal of fungi (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Hassan E EldesoukyDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
Abdelrahman MayhoubDepartment of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
Tony R HazbunDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.
Mohamed N SeleemDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA mseleem@purdue.edu.
Purdue University West Lafayette · USAl-Azhar University · EG

Funding

Repurposing auranofin and ebselen for treatment of multidrug resistant pathogensR01AI130186 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SELEEM, MOHAMED · 2017 to 2021
$2.3M
NIAID NIH HHS R01 AI130186
6 · The paper itself

Abstract

Invasive candidiasis presents an emerging global public health challenge due to the emergence of resistance to the frontline treatment options, such as fluconazole. Hence, the identification of other compounds capable of pairing with fluconazole and averting azole resistance would potentially prolong the clinical utility of this important group. In an effort to repurpose drugs in the field of antifungal drug discovery, we explored sulfa antibacterial drugs for the purpose of reversing azole resistance in

Indexed as

AnimalsAnti-Bacterial AgentsAntifungal AgentsAzolesBiofilmsCaenorhabditis elegansCandida albicansFluconazoleMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAzolesFluconazoleantifungalazole resistancebiofilmCaenorhabditis elegansCandida albicansfluconazole resistancesulfa antibacterial

Identifiers

PMID29263071
PMCPMC5826110
OpenAlexW2775932866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.