Evidence map›Paper›PMID 29263034›Full record

ArticleJournal of the American Heart Association2017

Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations.

Michal Schäfer, Alex J Barker, Vitaly Kheyfets, Kurt R Stenmark, James Crapo, Michael E Yeager, Uyen Truong, J Kern Buckner, Brett E Fenster, Kendall S Hunter

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Imaging in chronic thromboembolic pulmonary hypertension: review of the current literature.Diagnostic and interventional radiology (Ankara, Turkey) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A Non-Invasive Approach to Pulmonary Hypertension.Journal of clinical medicine · 2025
    Review
  11. Article
  12. Review
  13. Characterization of pulmonary arterial stiffness using cardiac MRI.The international journal of cardiovascular imaging · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. 4D flow cardiovascular magnetic resonance recovery profiles following pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Michal SchäferDivision of Cardiology, National Jewish Health, Denver, CO michal.schafer@ucdenver.edu.
Alex J BarkerDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Vitaly KheyfetsDepartment of Bioengineering, University of Colorado Denver | Anschutz Medical Campus, Denver, CO.
Kurt R StenmarkDepartment of Bioengineering, University of Colorado Denver | Anschutz Medical Campus, Denver, CO.
James CrapoDivision of Pulmonary Medicine, National Jewish Health, Denver, CO.
Michael E YeagerDepartment of Bioengineering, University of Colorado Denver | Anschutz Medical Campus, Denver, CO.
Uyen TruongDivision of Cardiology, National Jewish Health, Denver, CO.
J Kern BucknerDivision of Cardiology, National Jewish Health, Denver, CO.
Brett E FensterDivision of Cardiology, National Jewish Health, Denver, CO.
Kendall S HunterDivision of Cardiology, National Jewish Health, Denver, CO.
National Jewish Health · USUniversity of Colorado Denver · USChildren's Hospital Colorado · USNorthwestern University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1M
Fibroblasts and Mononuclear Fibrogenic Cells Drive Right Ventricular Pulmonary ArR01HL114887 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BULL, TODD M, BUTTRICK, PETER N. · 2012 to 2016
$3.4M
NHLBI NIH HHS P01 HL014985NHLBI NIH HHS R01 HL114887
6 · The paper itself

Abstract

backgroundQualitative and quantitative flow hemodynamic indexes have been shown to reflect right ventricular (RV) afterload and function in pulmonary hypertension (PH). We aimed to quantify flow hemodynamic formations in pulmonary arteries using 4-dimensional flow cardiac magnetic resonance imaging and the spatial velocity derivatives helicity and vorticity in a heterogeneous PH population. METHODS AND

resultsPatients with PH (n=35) and controls (n=10) underwent 4-dimensional flow magnetic resonance imaging study for computation of helicity and vorticity in the main pulmonary artery (MPA), the right pulmonary artery, and the RV outflow tract. Helicity and vorticity were correlated with standard RV volumetric and functional indexes along with MPA stiffness assessed by measuring relative area change. Patients with PH had a significantly decreased helicity in the MPA (8 versus 32 m/s

conclusionsThe flow hemodynamic character in patients with PH assessed via quantitative analysis is considerably different when compared with healthy and normotensive controls. A strong association between helicity in pulmonary arteries and ventricular-vascular coupling suggests a relationship between the mechanical and flow hemodynamic domains.

Indexed as

Blood Flow VelocityCardiac CatheterizationFemaleFollow-Up StudiesHeart VentriclesHumansHypertension, PulmonaryImage Processing, Computer-AssistedMagnetic Resonance AngiographyMagnetic Resonance Imaging, CineMaleMiddle AgedProspective StudiesPulmonary ArteryPulmonary Wedge PressureStroke Volumeflow imaginghemodynamicsmagnetic resonance imagingpulmonary hypertension

Identifiers

PMID29263034
PMCPMC5779020
OpenAlexW2780715958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.