Evidence map›Paper›PMID 29262642›Full record

ArticleOncotarget2017

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent.

Bernadette V Marquez-Nostra, Supum Lee, Richard Laforest, Laura Vitale, Xingyu Nie, Krzysztof Hyrc, Tibor Keler, Thomas Hawthorne, Jeremy Hoog, Shunqiang Li and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  8. Development of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Bernadette V Marquez-NostraMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Supum LeeMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Richard LaforestMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Laura VitaleCelldex Therapeutics, Hampton, NJ, USA.
Xingyu NieMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Krzysztof HyrcThe Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Tibor KelerCelldex Therapeutics, Hampton, NJ, USA.
Thomas HawthorneCelldex Therapeutics, Hampton, NJ, USA.
Jeremy HoogDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Shunqiang LiDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Farrokh DehdashtiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Cynthia X MaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mallinckrodt (United States) · USCelldex Therapeutics (United States) · USWashington University in St. Louis · USHope Center for Neurological Disorders · USUniversity of Alabama at Birmingham · USYale University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ACQUISITION OF THE INVEON SMALL ANIMAL PET/CT SYSTEMS10RR025097 · NCRR · WASHINGTON UNIVERSITY · PI LAFOREST, RICHARD ANDRE · 2009 to 2009
$989k
Imaging for Assessment and Prediction of Response to Therapy in Triple Negative Breast CancerR00CA201601 · NCI · YALE UNIVERSITY · PI MARQUEZ-NOSTRA, BERNADETTE · 2017 to 2019
$747k
WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCES10RR027552 · NCRR · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2010 to 2010
$275k
IMAGING FOR ASSESSMENT AND PREDICTION OF RESPONSE TO THERAPY FOR TRIPLE NEGATIVE BREAST CANCERK99CA201601 · NCI · WASHINGTON UNIVERSITY · PI MARQUEZ-NOSTRA, BERNADETTE · 2016 to 2017
$191k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K99 CA201601NCI NIH HHS P30 CA091842NCI NIH HHS R00 CA201601NCRR NIH HHS S10 RR025097NCRR NIH HHS S10 RR027552
6 · The paper itself

Abstract

High levels of expression of glycoprotein non-metastatic B (gpNMB) in triple negative breast cancer (TNBC) and its association with metastasis and recurrence make it an attractive target for therapy with the antibody drug conjugate, glembatumumab vedotin (CDX-011). This report describes the development of a companion PET-based diagnostic imaging agent using

Indexed as

dosimetryglembatumumabglycoprotein non-metastatic melanoma BPET imagingtriple negative breast cancer

Identifiers

PMID29262642
PMCPMC5732808
OpenAlexW2766949926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.