Evidence map›Paper›PMID 29262531›Full record

ArticleOncotarget2017

Mutational profile of primary breast diffuse large B-cell lymphoma.

Fernando Franco, Julia González-Rincón, Javier Lavernia, Juan F García, Paloma Martín, Carmen Bellas, Miguel A Piris, Lucia Pedrosa, José Miramón, José Gómez-Codina and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. A genetic profiling guideline to support diagnosis and clinical management of lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
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  14. MYD88Therapeutic advances in hematology · 2022
    Review
  15. Clinical Characteristics and Prognostic Factors in Primary Breast Diffuse Large B-Cell Lymphoma.Mediterranean journal of hematology and infectious diseases · 2022
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Fernando FrancoMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Julia González-RincónGroup of Research in Lymphomas, Medical Oncology Department, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.
Javier LaverniaGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
Juan F GarcíaPathology Department, MD Anderson Cancer Center, Madrid, Spain.
Paloma MartínCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Carmen BellasCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Miguel A PirisCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Lucia PedrosaGroup of Research in Lymphomas, Medical Oncology Department, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.
José MiramónGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
José Gómez-CodinaGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
Delvys Rodríguez-AbreuGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
Isidro MachadoPathology Department, Instituto Valenciano de Oncología, Valencia, Spain.
Carmen IlluecaPathology Department, Instituto Valenciano de Oncología, Valencia, Spain.
Jesús AlfaroGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
Mariano ProvencioMedical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Margarita Sánchez-BeatoGOTEL (Spanish Lymphoma Oncology Group), Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer · ESFundación Instituto Valenciano de Oncología · ESHospital Universitario Puerta de Hierro Majadahonda · ESInstituto de Investigación Sanitaria de Santiago · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario Fundación Jiménez Díaz · ESHospital Universitario Insular de Gran Canaria · ESMD Anderson Cancer Center Madrid · ESOnkologikoa · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary breast lymphoma is a rare form of extra-nodal lymphoid neoplasm. The most common histological type is the diffuse large B-cell lymphoma, which represents 60-80% of all the cases. Our study analyzes the mutational profile of the primary lymphoma of the breast through targeted massive sequencing with a panel of 38 genes in a group of 17 patients with primary breast diffuse large B-cell lymphoma. Seventy-point-five percent of the patients presented with stage IE and 29.5% with stage IIE. 44% of the cases correspond to lymphomas with germinal center phenotype and 33.3% to activated B-cell. The genes with a higher mutational frequency include

Indexed as

cell of origindiffuse large B-cell lymphomaNFkB pathwayPIM1primary breast lymphoma

Identifiers

PMID29262531
PMCPMC5732697
OpenAlexW2765890426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.