ArticleBiophysical journal2017
Prediction of Thylakoid Lipid Binding Sites on Photosystem II.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Low Carbon Inducible2/Fatty Acid Desaturase4 locus in C. reinhardtii directs plastid peroxidase location and trans fatty acid production.Plant physiology · 2025Article
- Molecular level insight into non-bilayer structure formation in thylakoid membranes: a molecular dynamics study.Photosynthesis research · 2025Article
- X-Ray Crystal and Cryo-Electron Microscopy Structure Analysis Unravels How the Unique Thylakoid Lipid Composition Is Utilized by CytochromeMembranes · 2025Article
- Martini 3 Coarse-Grained Model for the Cofactors Involved in Photosynthesis.International journal of molecular sciences · 2024Article
- Effects of lipids on the rate-limiting steps in the dark-to-light transition of Photosystem II core complex ofFrontiers in plant science · 2024Article
- Thermal site energy fluctuations in photosystem I: new insights from MD/QM/MM calculations.Chemical science · 2023Article
- The impact of physiologically relevant temperatures on physical properties of thylakoid membranes: a molecular dynamics study.Photosynthetica · 2023Article
- Protein dynamics and lipid affinity of monomeric, zeaxanthin-binding LHCII in thylakoid membranes.Biophysical journal · 2022Article
- Molecular dynamics simulations in photosynthesis.Photosynthesis research · 2020Review
- Molecular mechanism for bidirectional regulation of CD44 for lipid raft affiliation by palmitoylations and PIP2.PLoS computational biology · 2020Article
- Distinct structural modulation of photosystem I and lipid environment stabilizes its tetrameric assembly.Nature plants · 2020Article
- Specific Composition of Lipid Phases Allows Retaining an Optimal Thylakoid Membrane Fluidity in Plant Response to Low-Temperature Treatment.Frontiers in plant science · 2020Article
- Lipid Dependence of Xanthophyll Cycling in Higher Plants and Algae.Frontiers in plant science · 2020Review
- Emerging Diversity in Lipid-Protein Interactions.Chemical reviews · 2019Review
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Lipid Fingerprints and Cofactor Dynamics of Light-Harvesting Complex II in Different Membranes.Biophysical journal · 2019Article
- Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.Structure (London, England : 1993) · 2019Article
- Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology.The Journal of membrane biology · 2018Review
- Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.ACS central science · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thylakoid membrane has a unique lipid composition, consisting mostly of galactolipids. These thylakoid lipids have important roles in photosynthesis. Here, we investigate to what extent these lipids bind specifically to the Photosystem II complex. To this end, we performed coarse-grain MD simulations of the Photosystem II complex embedded in a thylakoid membrane with realistic composition. Based on >85 μs simulation time, we find that monogalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol lipids are enriched in the annular shell around the protein, and form distinct binding sites. From the analysis of residue contacts, we conclude that electrostatic interactions play an important role in stabilizing these binding sites. Furthermore, we find that chlorophyll a has a prevalent role in the coordination of the lipids. In addition, we observe lipids to diffuse in and out of the plastoquinone exchange cavities, allowing exchange of cocrystallized lipids with the bulk membrane and suggesting a more open nature of the plastoquinone exchange cavity. Together, our data provide a wealth of information on protein-lipid interactions for a key protein in photosynthesis.
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