ArticleImmunity2017
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Regulation of Intestinal Inflammation by Dietary Fats.Frontiers in immunology · 2020Pooled it
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology.JCI insight · 2026Article
- Integrating bile acid metabolism into precision nutrition strategies for improved swine performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic Switch.Journal of xenobiotics · 2026Article
- Nbeal2 Inactivation Triggers Abl1 Stabilisation and Dysregulated Subcellular Localisation of the Multi-Drug-Resistant Protein MDR1 (ABCB1) in Mast Cells.Immunology · 2026Article
- Engineering Tfh-Specific Nanoadjuvant to Counteract Bile Acid-Induced Mitophagy and Vaccine Hyporesponsivenes.Theranostics · 2026Article
- MDR1 promotes CD8 T cell persistence in tumors and protects against cytotoxic chemotherapy.bioRxiv : the preprint server for biology · 2025Article
- Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells.Nature communications · 2025Article
- An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice.Nature communications · 2025Article
- Bile acid synthesis impedes tumor-specific T cell responses during liver cancer.Science (New York, N.Y.) · 2025Article
- Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies.Frontiers in immunology · 2025Review
- P-glycoprotein expression skews mitochondrial dye measurements in T cells.Frontiers in immunology · 2025Article
- Natural Product-based Therapies for Inflammatory Bowel Disease: Targeting Key Signaling Pathways.Mini reviews in medicinal chemistry · 2025Review
- Novel insights and an updated review of metabolic syndrome in immune-mediated organ transplant rejection.Frontiers in immunology · 2025Review
- Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing.Nature communications · 2024Article
- Sulfated bile acid is a host-derived ligand for MAIT cells.Science immunology · 2024Article
- Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression.JCI insight · 2024Article
- A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application.Frontiers in immunology · 2024Review
- Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
23 authors at 9 institutions in 2 countries.
Wei CaoDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Hisako KayamaDepartment of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Mei Lan ChenDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Amber DelmasDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Amy SunDepartment of Pathology , New York University School of Medicine, New York, NY 10016, USA.
Sang Yong KimRodent Genetic Engineering Core , New York University School of Medicine, New York, NY 10016, USA.
Erumbi S RangarajanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Kelly McKevittDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Amanda P BeckDepartment of Veterinary Sciences, MD Anderson Cancer Center, Bastrop, TX 78602, USA.
Cody B JacksonDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Gogce CrynenBioinformatics Core Facility, The Scripps Research Institute, Jupiter, FL 33458, USA.
Angelos OikonomopoulosVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Precious N LaceyVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Gustavo J MartinezDepartment of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Tina IzardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.
Robin G LorenzDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Alex Rodriguez-PalaciosDigestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Fabio CominelliDigestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Maria T AbreuDivision of Gastroenterology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Daniel W HommesVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Sergei B KoralovDepartment of Pathology , New York University School of Medicine, New York, NY 10016, USA.
Kiyoshi TakedaDepartment of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Mark S SundrudDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: msundrud@scripps.edu.
Scripps Research Institute · USNew York University · USUniversity of California, Los Angeles · USCase Western Reserve University · USOsaka University · JPRosalind Franklin University of Medicine and Science · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alabama at Birmingham · USUniversity of Miami · US
Funding
Ubiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RODRIGUEZ-PALACIOS, ALEXANDER · 2011 to 2020
$16.5MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6MINNATE AND ADAPTIVE MICROBIAL IMMUNITY IN IBDP01DK071176 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELSON, CHARLES O · 2005 to 2014
$12.5MMECHANISMS OF EXPERIMENTAL CROHNS DISEASER01DK055812 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2019
$4.9MCYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7MRole of TLR4 in Colitis Associated NeoplasiaR01DK099076 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Maria Teresa Abreu · 2014 to 2026
$4.7MMicrobial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1R01HL125816 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2015 to 2019
$3.3MBile acid-dependent T cell regulation in the intestineR01AI143821 · NIAID · UNIVERSITY OF FLORIDA · PI SUNDRUD, MARK SCOTT · 2019 to 2023
$2.2MTranscriptional control of Intestinal CD4+ T cell adaptionR21AI119728 · NIAID · SCRIPPS FLORIDA · PI SUNDRUD, MARK SCOTT · 2015 to 2016
$528kGeneration of a mouse expressing a photoactivatable Cre recombinaseR21AI124129 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH, SCHWAB, SUSAN RUTH · 2016 to 2017
$466kNHLBI NIH HHS R01 HL125816NIAID NIH HHS R01 AI143821NIAID NIH HHS R21 AI119728NIAID NIH HHS R21 AI124129NIDDK NIH HHS P01 DK071176NIDDK NIH HHS P01 DK091222NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R01 DK055812NIDDK NIH HHS R01 DK099076
Abstract
CD4
Indexed as
AcridinesAdultAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Bile Acids and SaltsBiological TransportCD4-Positive T-LymphocytesCrohn DiseaseDisease Models, AnimalFemaleGene Expression RegulationHomeodomain ProteinsHomeostasisHumansIleitisIleumAcridinesATP Binding Cassette Transporter, Subfamily B, Member 1Bile Acids and SaltsElacridarHomeodomain ProteinsRAG-1 proteinTetrahydroisoquinolinesbile acidscholestyramineCrohn’s diseaseIBDileitisMDR1T cellsTh1Th17
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.