ArticleCell reports2017
Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Controlled release of coated antioxidants inhibits Citrobacter rodentium colonization in the colon of rats by reducing gut redox potential.Redox biology · 2026Article
- Multifunctional antimicrobial effects ofFrontiers in immunology · 2026Article
- Improved adhesion and function of Pediococcus pentosaceus Li05 for acute colitis through surface modification.NPJ science of food · 2025Article
- ComparingGut microbes · 2025Article
- The gut microbiota-independent virulence of noninvasive bacterial pathogen Citrobacter rodentium.PLoS pathogens · 2024Article
- Metabolism of L-arabinose converges with virulence regulation to promote enteric pathogen fitness.Nature communications · 2024Article
- Infection and antibiotic-associated changes in the fecal microbiota ofAntimicrobial agents and chemotherapy · 2024Article
- Epigenetic programming mediates abnormal gut microbiota and disease susceptibility in offspring with prenatal dexamethasone exposure.Cell reports. Medicine · 2024Article
- Article
- Simulated Colonic Fluid Replicates theInfection and immunity · 2022Article
- Dysbiosis in the Gut Microbiota in Patients with Inflammatory Bowel Disease during Remission.Microbiology spectrum · 2022Article
- Trained ILC3 responses promote intestinal defense.Science (New York, N.Y.) · 2022Article
- Geographic differences in gut microbiota composition impact susceptibility to enteric infection.Cell reports · 2021Article
- TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.JCI insight · 2021Article
- Health Monitoring of Laboratory Rodent Colonies-Talking about (R)evolution.Animals : an open access journal from MDPI · 2021Review
- Western-style diet impedes colonization and clearance of Citrobacter rodentium.PLoS pathogens · 2021Article
- Overview of the Effect of Citrobacter rodentium Infection on Host Metabolism and the Microbiota.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Advances and Challenges in Studying Type III Secretion Effectors of Attaching and Effacing Pathogens.Frontiers in cellular and infection microbiology · 2020Article
- Long-Term Effects of Early-Life Antibiotic Exposure on Resistance to Subsequent Bacterial Infection.mBio · 2019Article
- Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis.Infection and immunity · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigated the role of commensals at the peak of infection with the colonic mouse pathogen Citrobacter rodentium. Bioluminescent and kanamycin (Kan)-resistant C. rodentium persisted avirulently in the cecal lumen of mice continuously treated with Kan. A single Kan treatment was sufficient to displace C. rodentium from the colonic mucosa, a phenomenon not observed following treatment with vancomycin (Van) or metronidazole (Met). Kan, Van, and Met induce distinct dysbiosis, suggesting C. rodentium relies on specific commensals for colonic colonization. Expression of the master virulence regulator ler is induced in germ-free mice, yet C. rodentium is only seen in the cecal lumen. Moreover, in conventional mice, a single Kan treatment was sufficient to displace C. rodentium constitutively expressing Ler from the colonic mucosa. These results show that expression of virulence genes is not sufficient for colonization of the colonic mucosa and that commensals are essential for a physiological infection course.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.