ArticleAmerican journal of respiratory cell and molecular biology2018
PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β
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Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Phosphodiesterase signaling in asthma: mechanistic insights and emerging therapeutic strategies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Phosphodiesterase 8 regulation of excitation-contraction coupling as a target for cardiovascular disease: is it my turn now?American journal of physiology. Heart and circulatory physiology · 2026Review
- Oligomerization of transmembrane adenylyl cyclase isoforms.Molecular pharmacology · 2026Review
- Cyclic nucleotide phosphodiesterases as drug targets.Pharmacological reviews · 2025Review
- Advancing Obstructive Airway Disease Treatment: Dual PDE3/4 Inhibition as a Therapeutic Strategy.Cells · 2025Review
- Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling inCells · 2025Review
- Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.Circulation research · 2024Article
- PDE4 Inhibitors and their Potential Combinations for the Treatment of Chronic Obstructive Pulmonary Disease: A Narrative Review.The open respiratory medicine journal · 2024Review
- Therapeutic Targets and Precision Medicine in COPD: Inflammation, Ion Channels, Both, or Neither?International journal of molecular sciences · 2023Review
- Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle.American journal of respiratory cell and molecular biology · 2023Article
- Article
- Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells.Frontiers in physiology · 2023Article
- Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders.Inflammopharmacology · 2022Review
- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
- Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8).Cells · 2022Article
- Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates.EBioMedicine · 2021Article
- Phosphodiesterase Inhibitors in Acute Lung Injury: What Are the Perspectives?International journal of molecular sciences · 2021Review
- The Role of PDE8 in T Cell Recruitment and Function in Inflammation.Frontiers in cell and developmental biology · 2021Review
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Authors and funding
11 authors at 5 institutions in 1 country.
Timothy B Johnstone1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Kaitlyn H Smith2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Cynthia J Koziol-White3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Fengying Li2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Austin G Kazarian1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Maia L Corpuz1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Maya Shumyatcher4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Frederick J Ehlert5 Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California.
Blanca E Himes4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Reynold A Panettieri3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Rennolds S Ostrom1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Chapman University · USRutgers, The State University of New Jersey · USUniversity of Pennsylvania · USUniversity of Tennessee Health Science Center · USUniversity of California, Irvine · US
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3MCEBPD-Mediated Mechanisms of Glucocorticoid Insensitivity in Severe AsthmaR01HL133433 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HIMES, BLANCA E · 2017 to 2021
$3.2MMolecular signal transduction of cAMP compartmentsR01GM107094 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI OSTROM, RENNOLDS S · 2015 to 2022
$2.3MNHLBI NIH HHS R01 HL133433NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R01 GM107094
Abstract
Two cAMP signaling compartments centered on adenylyl cyclase (AC) exist in human airway smooth muscle (HASM) cells, one containing β
Indexed as
3',5'-Cyclic-AMP PhosphodiesterasesAdenylyl CyclasesAirway RemodelingAsthmaCase-Control StudiesCell ProliferationCells, CulturedCyclic AMPHumansMembrane MicrodomainsMuscle, SmoothMyocytes, Smooth MuscleReceptors, Adrenergic, beta-2Respiratory SystemSecond Messenger SystemsTime Factors3',5'-Cyclic-AMP Phosphodiesterasesadenylyl cyclase 6Adenylyl CyclasesADRB2 protein, humanCyclic AMPPDE8A protein, humanReceptors, Adrenergic, beta-2adenylyl cyclasecAMP compartmentationlipid raftsPDE
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.