ArticlePLoS biology2017
Key scientific issues in developing drinking water guidelines for perfluoroalkyl acids: Contaminants of emerging concern.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 132 citations in OpenAlex.
- Per- and polyfluoroalkyl substances in commercially important marine species of fish and shellfish from Alaska and implications for human exposure.Toxicology reports · 2026Article
- Occurrence and Distribution Profiles of Perfluoroalkyl and Polyfluoroalkyl Substances in Water and Sediment of the Lower Reaches of the Yellow River.Water environment research : a research publication of the Water Environment Federation · 2026Article
- Evaluation of isotope-dilution mass spectrometry, internal standard, and external standard methods for PFAS quantification in tap water and soil.Analytical and bioanalytical chemistry · 2026Article
- Rethinking PFAS Behavior in Phosphogypsum Stacks: A Hydrochemically Controlled Multiphase Perspective.Molecules (Basel, Switzerland) · 2026Article
- PFAS and One Health: integrating human, animal, and environmental perspectives.Archives of toxicology · 2026Review
- Sociodemographic predictors of PFAS exposure among a combined sample of U.S. pregnant women: an Environmental influences on Child Health Outcomes (ECHO) public-use dataset analysis.Journal of exposure science & environmental epidemiology · 2026Article
- Efficacy and Threat Language in PFAS Messaging.Risk analysis : an official publication of the Society for Risk Analysis · 2026Article
- Health risk assessment of perfluorinated compounds in the drinking water of a watershed located in northwest China in 2024: a cross-sectional study.Journal of water and health · 2026Article
- Impact of regulatory actions to establish maximum contaminant levels on per- and polyfluoroalkyl substances in New Jersey public water systems.Environment international · 2026Article
- Managing PFAS in Sewage Sludge: Exposure Pathways, Impacts, and Treatment Innovations.Journal of xenobiotics · 2025Review
- A Global Overview of Per- and Polyfluoroalkyl Substance Regulatory Strategies and Their Environmental Impact.Toxics · 2025Article
- Per- and Polyfluoroalkyl Substance (PFAS) Degradation in Water and Soil Using Cold Atmospheric Plasma (CAP): A Review.ACS physical chemistry Au · 2025Review
- Considerations and challenges in support of science and communication of fish consumption advisories for per- and polyfluoroalkyl substances.Integrated environmental assessment and management · 2024Review
- Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice.The Science of the total environment · 2024Article
- Emergency of per- and polyfluoroalkyl substances in drinking water: Status, regulation, and mitigation strategies in developing countries.Eco-Environment & Health · 2024Review
- The role of exposure to per- and polyfluoroalkyl substances in racial/ethnic disparities in hypertension: Results from the study of Women's health across the nation.Environmental research · 2023Article
- Community-facing toxicokineticmodels to estimate PFAS serum levels based on life history and drinking water exposures.Environment international · 2023Article
- PFOS Impairs Mitochondrial Biogenesis and Dynamics and Reduces Oxygen Consumption in Human Trophoblasts.Journal of environmental science and public health · 2023Article
- Toxicokinetic Modeling of Per- and Polyfluoroalkyl Substance Concentrations within Developing Zebrafish (Environmental science & technology · 2022Article
- Official health communications are failing PFAS-contaminated communities.Environmental health : a global access science source · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perfluoroalkyl acids (PFAAs), a group of synthetic organic chemicals with industrial and commercial uses, are of current concern because of increasing awareness of their presence in drinking water and their potential to cause adverse health effects. PFAAs are distinctive among persistent, bioaccumulative, and toxic (PBT) contaminants because they are water soluble and do not break down in the environment. This commentary discusses scientific and risk assessment issues that impact the development of drinking water guidelines for PFAAs, including choice of toxicological endpoints, uncertainty factors, and exposure assumptions used as their basis. In experimental animals, PFAAs cause toxicity to the liver, the immune, endocrine, and male reproductive systems, and the developing fetus and neonate. Low-dose effects include persistent delays in mammary gland development (perfluorooctanoic acid; PFOA) and suppression of immune response (perfluorooctane sulfonate; PFOS). In humans, even general population level exposures to some PFAAs are associated with health effects such as increased serum lipids and liver enzymes, decreased vaccine response, and decreased birth weight. Ongoing exposures to even relatively low drinking water concentrations of long-chain PFAAs substantially increase human body burdens, which remain elevated for many years after exposure ends. Notably, infants are a sensitive subpopulation for PFAA's developmental effects and receive higher exposures than adults from the same drinking water source. This information, as well as emerging data from future studies, should be considered in the development of health-protective and scientifically sound guidelines for PFAAs in drinking water.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.