Evidence map›Paper›PMID 29261226›Full record

ArticleCurrent protocols in pharmacology2017

In Vitro Assays for the Functional Characterization of the Dopamine Transporter (DAT).

Shaili Aggarwal, Ole V Mortensen

Abstract read
In one paragraph

Article in Current protocols in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shaili AggarwalDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Ole V MortensenDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Funding

Computational and functional studies of allosteric monoamine transporter modulationR01MH106912 · NIMH · DREXEL UNIVERSITY · PI KORTAGERE, SANDHYA, MORTENSEN, OLE VALENTE · 2015 to 2019
$2.0M
NIMH NIH HHS R01 MH106912
6 · The paper itself

Abstract

Detailed in this unit are protocols for studying the in vitro uptake of dopamine (DA) as a means for defining the functional characteristics of dopamine transporters. All assays are performed using commercially available cell lines that transiently express the transporter under investigation. The three main assays provided are: a kinetic assay to calculate the affinity (K

Indexed as

AnimalsBiological AssayCell LineDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsDose-Response Relationship, DrugHumansKineticsLigandsDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsLigandsdopamine transportermonoamineneurotransmitteruptake

Identifiers

PMID29261226
PMCPMC5741089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.