Evidence map›Paper›PMID 29260690›Full record

ArticleEmerging infectious diseases2018

Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015.

Maria Dolores Fernandez-Garcia, Manasi Majumdar, Ousmane Kebe, Aichatou D Fall, Moussa Kone, Mouctar Kande, Moustapha Dabo, Mohamed Salif Sylla, Djenou Sompare, Wayne Howard and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Effects of public health emergencies of international concern on disease control: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Maria Dolores Fernandez-Garcia
Manasi Majumdar
Ousmane Kebe
Aichatou D Fall
Moussa Kone
Mouctar Kande
Moustapha Dabo
Mohamed Salif Sylla
Djenou Sompare
Wayne Howard
Ousmane Faye
Javier Martin
Kader Ndiaye
National Institute for Communicable DiseasesNational Institute for Biological Standards and Control · GBInstitut Pasteur de Dakar · SN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the 2014-2015 outbreak of Ebola virus disease in Guinea, 13 type 2 circulating vaccine-derived polioviruses (cVDPVs) were isolated from 6 polio patients and 7 healthy contacts. To clarify the genetic properties of cVDPVs and their emergence, we combined epidemiologic and virologic data for polio cases in Guinea. Deviation of public health resources to the Ebola outbreak disrupted polio vaccination programs and surveillance activities, which fueled the spread of neurovirulent VDPVs in an area of low vaccination coverage and immunity. Genetic properties of cVDPVs were consistent with their capacity to cause paralytic disease in humans and capacity for sustained person-to-person transmission. Circulation ceased when coverage of oral polio vaccine increased. A polio outbreak in the context of the Ebola virus disease outbreak highlights the need to consider risks for polio emergence and spread during complex emergencies and urges awareness of the challenges in polio surveillance, vaccination, and diagnosis.

Indexed as

Amino Acid SubstitutionBase SequenceDisease OutbreaksFecesGenome, ViralGlobal HealthGuineaHemorrhagic Fever, EbolaHumansImmunocompromised HostPhylogenyPoliomyelitisPoliovirusPoliovirus Vaccine, OralPublic HealthVaccinationPoliovirus Vaccine, OralViral Proteinsacute flaccid paralysisEbola outbreakGuineavaccinationvaccine-derived poliovirusvaccinesviruses

Identifiers

PMID29260690
PMCPMC5749474
OpenAlexW2773354873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.