Evidence map›Paper›PMID 29260627›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke.

Catherine McCaig, Paris Ataliotis, Anan Shtaya, Ayan S Omar, A Richard Green, Clive N Kind, Anthony C Pereira, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Rafael J Yáñez-Muñoz and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  6. Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Catherine McCaig1 Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.
Paris Ataliotis2 Institute for Medical & Biomedical Education, St George's University of London, London, UK.
Anan Shtaya1 Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.
Ayan S Omar1 Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.
A Richard Green3 School of Life Sciences, University of Nottingham, Nottingham, UK.
Clive N Kind4 Leicester School of Pharmacy, De Montfort University, Leicester, UK.
Anthony C Pereira1 Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.
Aniko Naray-Fejes-Toth6 Molecular & Systems Biology Department, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Geza Fejes-Toth6 Molecular & Systems Biology Department, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Rafael J Yáñez-Muñoz7 AGCTlab.org, Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK.
James T Murray8 School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Atticus H Hainsworth1 Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.
St George's, University of London · GBDartmouth College · USDe Montfort University · GBRoyal Holloway University of London · GBTrinity College Dublin · IEUniversity of Nottingham · GB

Funding

Department of HealthMedical Research Council G1000691Medical Research Council MR/L022656/1
6 · The paper itself

Abstract

Nitrones (e.g. α-phenyl-N-tert-butyl nitrone; PBN) are cerebroprotective in experimental stroke. Free radical trapping is their proposed mechanism. As PBN has low radical trapping potency, we tested Sgk1 induction as another possible mechanism. PBN was injected (100 mg/kg, i.p.) into adult male rats and mice. Sgk1 was quantified in cerebral tissue by microarray, quantitative RT-PCR and western analyses. Sgk1

Indexed as

AnimalsBrainBrain IschemiaCyclic N-OxidesImmediate-Early ProteinsInfarction, Middle Cerebral ArteryMaleMiceMice, KnockoutNitrogen OxidesProtein Serine-Threonine KinasesRatsSerum-Glucocorticoid Regulated KinasesStrokeTranscriptional ActivationCyclic N-OxidesImmediate-Early ProteinsNitrogen Oxidesnitronesphenyl-N-tert-butylnitroneProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesSGK3 protein, ratAcute strokeanimal modelsfocal ischemialacunar infarctsneuroprotection

Identifiers

PMID29260627
PMCPMC6545623
OpenAlexW2781338425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.