ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
Preliminary evidence for cerebral capillary shunting in adults with sickle cell anemia.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Cerebral Blood Transit in Sickle Cell Anemia.Journal of magnetic resonance imaging : JMRI · 2026Article
- Cerebral vascular shunting and oxygen metabolism in sickle cell disease.Blood advances · 2025Article
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Venous arterial spin labeling MRI signal is associated with oxygen supply-independent reduction in cerebral oxygen extraction in typically aging older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Novel identifications of cerebral hemodynamics using BOLD fMRI in patients with sickle cell disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia.HemaSphere · 2024Article
- Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease.Blood advances · 2024Article
- A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?Fluids and barriers of the CNS · 2023Article
- Red cell exchange transfusions increase cerebral capillary transit times and may alter oxygen extraction in sickle cell disease.NMR in biomedicine · 2023Article
- Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.Magnetic resonance in medicine · 2023Article
- Assessment of functional shunting in patients with sickle cell disease.Haematologica · 2022Article
- Oxygen extraction efficiency and white matter lesion burden in older adults exhibiting radiological evidence of capillary shunting.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Multidelay ASL of the pediatric brain.The British journal of radiology · 2022Review
- Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex.Frontiers in physiology · 2022Article
- Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study.Frontiers in physiology · 2022Article
- Chronic anemia: The effects on the connectivity of white matter.Frontiers in neurology · 2022Article
- Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias.American journal of hematology · 2021Article
- Elevated cerebral blood flow in patients with pure autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Reduced oxygen extraction efficiency in sickle cell anemia patients with evidence of cerebral capillary shunting.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Elevated flow velocities in adults with sickle cell anemia (SCA) may cause rapid erythrocyte transit through capillaries. This phenomenon could present as dural venous sinus hyperintensity on arterial spin labeling (ASL)-MRI and could be indicative of capillary shunting. Here, the prevalence of ASL venous hyperintensities and association with relevant physiology in adults with SCA was investigated. SCA ( n = 46) and age-matched control ( n = 16) volunteers were recruited for 3.0 T MRI. Pseudo-continuous ASL-MRI was acquired for cerebral blood flow (CBF) calculation and venous hyperintensity determination; venous signal intensity and a categorical venous score (three raters; 0 = no hyperintensity, 1 = focal hyperintensity, and 2 = diffuse hyperintensity) were recorded. Flow velocity in cervical internal carotid artery segments was determined from phase contrast data (v
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.