ArticleChemistry Central journal2017
Study of binding interaction of rivaroxaban with bovine serum albumin using multi-spectroscopic and molecular docking approach.
Article in Chemistry Central journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Unravelling the Interaction Mechanism Between Oryzanol and Human Serum Albumin: An Integrated Approach Using Multispectral Analysis and Molecular Simulations.Foods (Basel, Switzerland) · 2026Article
- Fabricating Zein-OSA Starch Complexes as Multifunctional Carriers for Carrot Oil.Foods (Basel, Switzerland) · 2026Article
- The development of an innovative method to improve the dissolution performance of rivaroxaban.Heliyon · 2024Article
- The mechanism of fluorescence quenching of naphthalimide A/C leak detector by copper (II).BMC chemistry · 2023Article
- Molecular Interaction Mechanism and Preservative Effect of Lactone Sophorolipid and Lactoferrin/Foods (Basel, Switzerland) · 2023Article
- Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies.International journal of molecular sciences · 2023Article
- Article
- Fermented Supernatants ofNutrients · 2023Article
- Cu(II) complex with auxin (3-indoleacetic acid) and an aromatic planar ligand: synthesis, crystal structure, biomolecular interactions and radical scavenging activity.European biophysics journal : EBJ · 2021Article
- Article
- Mechanistic interaction study of 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione with bovine serum albumin by spectroscopic and molecular docking approaches.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Mechanistic Interaction Study of Bromo-Noscapine with Bovine Serum Albumin employing Spectroscopic and Chemoinformatics Approaches.Scientific reports · 2018Article
- Study of Interactions of an Anticancer Drug Neratinib With Bovine Serum Albumin: Spectroscopic and Molecular Docking Approach.Frontiers in chemistry · 2018Article
- Spectroscopic and molecular modeling studies of binding interaction between bovine serum albumin and roflumilast.Drug design, development and therapy · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRivaroxaban is a direct inhibitor of coagulation factor Xa and is used for venous thromboembolic disorders. The rivaroxaban interaction with BSA was studied to understand its PK and PD (pharmacokinetics and pharmacokinetics) properties. Multi-spectroscopic studies were used to study the interaction which included UV spectrophotometric, spectrofluorometric and three dimensional spectrofluorometric studies. Further elucidation of data was done by molecular simulation studies to evaluate the interaction behavior between BSA and rivaroxaban.
resultsRivaroxaban quenched the basic fluorescence of BSA molecule by the process of static quenching since rivaroxaban and BSA form a complex that results in shift of the absorption spectra of BSA molecule. A decline in the values of binding constants was detected with the increase of temperatures (298-308 K) and the binding constants were in range from 1.32 × 10
conclusionsThe results of molecular docking were consistent with the results obtained from spectroscopic studies in establishing the principal binding site and type of bonds between rivaroxaban and BSA.
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