Evidence map›Paper›PMID 29260327›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2018

Cytotoxicity in vitro, cellular uptake, localization and apoptotic mechanism studies induced by ruthenium(II) complex.

Jincan Chen, Yao Zhang, Guodong Li, Fa Peng, Xinming Jie, Ji She, Guangzhi Dongye, Zhilin Zou, Shiwen Rong, Lanmei Chen

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  3. Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jincan ChenAnalysis Centre of Guangdong Medical University, Zhanjiang, 524023, China.
Yao ZhangDongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Guodong LiDongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Fa PengDongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Xinming JieAnalysis Centre of Guangdong Medical University, Zhanjiang, 524023, China.
Ji SheDongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
Guangzhi DongyeAnalysis Centre of Guangdong Medical University, Zhanjiang, 524023, China.
Zhilin ZouThe First Clinical Medical College, Guangdong Medical University, Zhanjiang, 524023, China.
Shiwen RongThe First Clinical Medical College, Guangdong Medical University, Zhanjiang, 524023, China.
Lanmei ChenDongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China. lanmeichen@126.com.ORCID 0000-0001-8149-4804
Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium-based complexes have been regarded as one of the most potential metal-based candidates for anticancer therapy. Herein, two ruthenium (II) methylimidazole complexes [Ru(MeIm)

Indexed as

ApoptosisCell Cycle CheckpointsCell LineCell Line, TumorDNA DamageG1 PhaseHumansMAP Kinase Signaling SystemMembrane Potential, MitochondrialProton Magnetic Resonance SpectroscopyReactive Oxygen SpeciesResting Phase, Cell CycleRuthenium CompoundsSpectrometry, Mass, Electrospray IonizationSpectrophotometry, UltravioletReactive Oxygen SpeciesRuthenium CompoundsApoptosisDNA damageMitochondrial dysfunctionROSRuthenium methylimidazole complex

Identifiers

PMID29260327
OpenAlexW2778807203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.