Evidence map›Paper›PMID 29260326›Full record

ArticleClinical oral investigations2018

Porous zirconia ceramic as an alternative to dentin for in vitro dentin barriers cytotoxicity test.

Meng-Long Hu, Hong Lin, Ruo-Dan Jiang, Li-Min Dong, Lin Huang, Gang Zheng

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meng-Long HuDental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Hong LinDental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Ruo-Dan JiangDental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Li-Min DongBeijing Key Laboratory of Fine Ceramics, Institute of Nuclear and New Energy Technology of Tsinghua University, Beijing, 102201, China.
Lin HuangBeijing Key Laboratory of Fine Ceramics, Institute of Nuclear and New Energy Technology of Tsinghua University, Beijing, 102201, China.
Gang ZhengDental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. zhenggang1952@163.com.ORCID http://orcid.org/0000-0001-5084-4314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study assessed the potential of porous zirconia ceramic as an alternative to dentin via an in vitro dentin barrier cytotoxicity test.

methodsThe permeability of dentin and porous zirconia ceramic was measured using a hydraulic-conductance system, and their permeability was divided into two groups: high and low. Using an in vitro dentin barrier test, the cytotoxicity of dental materials by dentin and porous zirconia ceramic was compared within the same permeability group. The L-929 cell viability was assessed by MTT assay.

resultsThe mean (SD) permeability of the high and low group for dentin was 0.334 (0.0873) and 0.147 (0.0377) μl min

conclusionsPorous zirconia ceramic, having similar permeability to dentin at the same thickness, can be used as an alternative to dentin for in vitro dentin barrier cytotoxicity tests. CLINICAL RELEVANCE: In vitro dentin barrier cytotoxicity tests when a standardized porous zirconia ceramic was used as a barrier could be useful for assessing the potential toxicity of new dental materials applied to dentin before applying in clinical and may resolve the issue of procuring human teeth when testing proceeds.

Indexed as

Cell SurvivalDental MaterialsDentinDentin PermeabilityHumansIn Vitro TechniquesMaterials TestingMolar, ThirdPorositySurface PropertiesZirconiumDental MaterialsZirconiumzirconium oxideCytotoxicityDental materialsDentin barrier testDentin permeabilityPorous zirconia ceramic

Identifiers

PMID29260326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.