Evidence map›Paper›PMID 29260309›Full record

ArticleLung2018

HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study.

Crystal M North, Joseph G Allen, Samson Okello, Ruth Sentongo, Bernard Kakuhikire, Edward T Ryan, Alexander C Tsai, David C Christiani, Mark J Siedner

Abstract read
In one paragraph

Article in Lung, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. HIV-associated lung disease.Nature reviews. Disease primers · 2023
    Review
  12. Factors Associated with Chronic Obstructive Pulmonary Disease: A Hospital-Based Case-Control Study.International journal of chronic obstructive pulmonary disease · 2023
    Article
  13. Article
  14. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023
    Review
  15. Observational
  16. The influence of smoking and HIV infection on pulmonary function.Southern African journal of HIV medicine · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. An Emerging Syndemic of Smoking and Cardiopulmonary Diseases in People Living with HIV in Africa.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Crystal M NorthDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, BUL-148, Boston, MA, 02114, USA. cnorth@mgh.harvard.edu.ORCID 0000-0002-6615-5385
Joseph G AllenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Samson OkelloMbarara University of Science and Technology, Mbarara, Uganda.
Ruth SentongoMbarara University of Science and Technology, Mbarara, Uganda.
Bernard KakuhikireMbarara University of Science and Technology, Mbarara, Uganda.
Edward T RyanHarvard Medical School, Boston, MA, USA.
Alexander C TsaiHarvard Medical School, Boston, MA, USA.
David C ChristianiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, BUL-148, Boston, MA, 02114, USA.
Mark J SiednerHarvard Medical School, Boston, MA, USA.
Harvard University · USMbarara University of Science and Technology · UG

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Research Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6M
Vanderbilt-Emory-Cornell-Duke Global Health Fellowship Consortium-Expanding Diversity for Global Equity (EDGE)D43TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALIYU, MUKTAR HASSAN, HEIMBURGER, DOUGLAS CORBETT · 2017 to 2021
$6.3M
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
Developing Research At The Interface Of HIV And AgingR24AG044325 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HIGH, KEVIN P. · 2013 to 2017
$2.4M
Microenterprise to empower and improve health of HIV+ women in UgandaK23MH096620 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2012 to 2016
$922k
Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
Epidemiology of atherosclerosis among older-age individuals with HIV in UgandaR21HL124712 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2014 to 2015
$332k
FIC NIH HHS D43 TW009337FIC NIH HHS R25 TW009337FIC NIH HHS R25TW009337National Institute of Allergy and Infectious Diseases P30AI060354NCATS NIH HHS UL1 TR001102NHLBI NIH HHS R21 HL124712NHLBI NIH HHS R21HL124712NHLBI NIH HHS T32 HL116275NHLBI NIH HHS T32HL116275NIAID NIH HHS P30 AI060354NIA NIH HHS R24 AG044325NIA NIH HHS R24AG044325NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIMH NIH HHS K23 MH096620NIMH NIH HHS K23MH096620NIMH NIH HHS K23 MH099916NIMH NIH HHS K23MH099916
6 · The paper itself

Abstract

purposeHIV is associated with chronic obstructive pulmonary disease (COPD) in high resource settings. Similar relationships are less understood in low resource settings. We aimed to estimate the association between HIV infection, tuberculosis, and COPD in rural Uganda.

methodsThe Uganda Non-communicable Diseases and Aging Cohort study observes people 40 years and older living with HIV (PLWH) on antiretroviral therapy, and population-based HIV-uninfected controls in rural Uganda. Participants completed respiratory questionnaires and post-bronchodilator spirometry.

resultsAmong 269 participants with spirometry, median age was 52 (IQR 48-55), 48% (n = 130) were ever-smokers, and few (3%, n = 9) reported a history of COPD or asthma. All participants with prior tuberculosis (7%, n = 18) were PLWH. Among 143 (53%) PLWH, median CD4 count was 477 cells/mm

conclusionIn rural Uganda, COPD may be more prevalent among PLWH, men, and those with prior tuberculosis. Future research is needed to confirm these findings and evaluate their broader impacts on health.

Indexed as

CD4 Lymphocyte CountComorbidityCross-Sectional StudiesFemaleForced Expiratory VolumeHIV InfectionsHumansMaleMiddle AgedPrevalencePulmonary Disease, Chronic ObstructiveRural PopulationSex FactorsSpirometrySurveys and QuestionnairesTuberculosis, PulmonaryAfricaAIDSLung functionSpirometryTuberculosis

Identifiers

PMID29260309
PMCPMC6261662
OpenAlexW2780923537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.