Evidence map›Paper›PMID 29260033›Full record

ArticleeNeurologicalSci2017

Inhibition of the primary motor cortex and the upgoing thumb sign.

Antonia Nucera, Mahmoud Reza Azarpazhooh, Lucilla Cardinali, Rasha Alsubaie, Tzu-Ching Chiang, Nina Weishaupt, Vladimir Hachinski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeurologicalSci, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Antonia NuceraDepartment of Clinical Neurological Science, University Hospital, University of Western Ontario, Ontario, Canada.
Mahmoud Reza AzarpazhoohDepartment of Clinical Neurological Science, University Hospital, University of Western Ontario, Ontario, Canada.
Lucilla CardinaliDepartment of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Rasha AlsubaieDepartment of Clinical Neurological Science, University Hospital, University of Western Ontario, Ontario, Canada.
Tzu-Ching ChiangThe Brain and Mind Institute, University of Western Ontario, Ontario, Canada.
Nina WeishauptDepartment of Anatomy and Cell Biology, University of Western Ontario, Ontario, Canada.
Vladimir HachinskiDepartment of Clinical Neurological Science, University Hospital, University of Western Ontario, Ontario, Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe upgoing thumb sign has been frequently observed in patients with minor strokes and transient ischemic attacks as an indicator of brain involvement. We assessed the effect of primary motor cortex (M1) inhibition in the development of the upgoing thumb sign.

methodsUsed repetitive Transcranial Magnetic Stimulation (rTMS, 1 Hz frequency for 15 min, 1s ISI, 900 pulses) at 60% of resting motor threshold to inhibit the right or left primary motor cortex of 10 healthy individuals. Participants were examined before and after rTMS by a neurologist who was blind to the site of motor cortex inhibition.

results10 neurological intact participants (5 women/5 men) were recruited for this study. 2 cases were excluded due to pre-existing possible thumb signs. After the inhibition of the primary motor cortex, in 6 subjects out of 8, we observed a thumb sign contralateral to the site of primary motor cortex inhibition. In one subject an ipsilateral thumbs sign was noted. In another case, we did not find an upgoing thumb sign.

conclusionThe upgoing thumb sign is a subtle neurological finding that may be related to the primary motor cortex or corticospinal pathways involvements.

Indexed as

Corticospinal tractPrimary motor cortexTranscranial magnetic stimulationUpper motor neuron lesions

Identifiers

PMID29260033
PMCPMC5730890
OpenAlexW2739406793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.