Evidence map›Paper›PMID 29259995›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2018

Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies.

Ann Ranger, Soma Ray, Suzanne Szak, Andrea Dearth, Norm Allaire, Ronald Murray, Rebecca Gardner, Diego Cadavid, Sha Mi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. The neuropathobiology of multiple sclerosis.Nature reviews. Neuroscience · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Treatment and Relapse Prevention of Typical and Atypical Optic Neuritis.International journal of molecular sciences · 2022
    Review
  10. Review
  11. Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Observational
  12. Article
  13. Article
  14. Review
  15. Approaches to Remyelination Therapies in Multiple Sclerosis.Current treatment options in neurology · 2019
    Review
  16. N2 year in review and message from the editor to our reviewers.Neurology(R) neuroimmunology & neuroinflammation · 2019
    Article
  17. Article
  18. Multiple sclerosis.Nature reviews. Disease primers · 2018
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ann RangerBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Soma RayBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Suzanne SzakBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Andrea DearthBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Norm AllaireBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Ronald MurrayBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Rebecca GardnerBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Diego CadavidBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
Sha MiBiogen (A.R., S.R., S.S., A.D., N.A., D.C., S.M.), Cambridge, MA; MS Clinic of Colorado and IMMUNOe International Research Centers (R.M.), Centennial; and Excel Scientific Solutions (R.G.), Horsham, UK. Dr. Ranger, Dr. Ray, Ms. Dearth, and Dr. Cadavid were employees of Biogen at the time of the studies but have since left the company.
IMMUNOe Research Center · USBiogen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether the anti-LINGO-1 antibody has immunomodulatory effects.

methodsHuman peripheral blood mononuclear cells (hPBMCs), rat splenocytes, and rat CD4

resultsLINGO-1 is not expressed in hPBMCs, rat splenocytes, or rat CD4

conclusionsThese data support the hypothesis that LINGO-1 blockade does not affect immune function. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that in patients with MS, opicinumab does not have immunomodulatory effects detected by changes in immune gene transcript expression.

Identifiers

PMID29259995
PMCPMC5732005
OpenAlexW2773077993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.