Evidence map›Paper›PMID 29259991›Full record

ArticleBioMed research international2017

Enhancement of Angiogenesis by Ultrasound-Targeted Microbubble Destruction Combined with Nuclear Localization Signaling Peptides in Canine Myocardial Infarction.

Jingjing Cui, Qing Deng, Qing Zhou, Sheng Cao, Nan Jiang, Yijia Wang, Jinling Chen, Bo Hu, Tuantuan Tan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jingjing CuiDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Qing DengDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Qing ZhouDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.ORCID 0000-0003-1694-2978
Sheng CaoDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Nan JiangDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Yijia WangDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Jinling ChenDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Bo HuDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Tuantuan TanDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430000, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to develop a gene delivery system using ultrasound-targeted microbubbles destruction (UTMD) combined with nuclear localization signal (NLS) and investigate its efficacy and safety for therapeutic angiogenesis in canine myocardial infarction (MI) model.

methodsFifty MI dogs were randomly divided into 5 groups and transfected with Ang-1 gene plasmid: (i) group A: only injection of microbubbles and Ang-1 plasmid; (ii) group B: only UTMD mediated gene transfection; (iii) group C: UTMD combined with classical NLS mediated gene transfection; (iv) group D: UTMD combined with mutational NLS mediated transfection; and (v) group E: UTMD combined with classical NLS in the presence of a nucleus transport blocker. The mRNA and protein expression of Ang-1 gene, microvessel density (MVD) cardiac troponin I (cTnI), and cardiac function were determined after transfection.

resultsThe expression of mRNA and protein of Ang-1 gene in group C was significantly higher than that of the other groups (all

conclusionsThe gene delivery system composed of UTMD and NLS is efficient and safe.

Indexed as

Gene Transfer TechniquesAnimalsDog DiseasesDogsGene Expression RegulationMicrobubblesMyocardial InfarctionRibonuclease, PancreaticRNA, MessengerTroponin IUltrasonic WavesangiogeninRibonuclease, PancreaticRNA, MessengerTroponin I

Identifiers

PMID29259991
PMCPMC5702398
OpenAlexW2767586883

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.