Evidence map›Paper›PMID 29259971›Full record

ArticleFrontiers in cell and developmental biology2017

ALK1Fc Suppresses the Human Prostate Cancer Growth in

Letizia Astrologo, Eugenio Zoni, Sofia Karkampouna, Peter C Gray, Irena Klima, Joël Grosjean, Marie J Goumans, Lukas J A C Hawinkels, Gabri van der Pluijm, Martin Spahn and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Letizia AstrologoDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Eugenio ZoniDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Sofia KarkampounaDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Peter C GrayClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, United States.
Irena KlimaDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Joël GrosjeanDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Marie J GoumansDepartment of Molecular Cell Biology, Cancer Genomics Center, Leiden University Medical Centre, Leiden, Netherlands.
Lukas J A C HawinkelsDepartment of Molecular Cell Biology, Cancer Genomics Center, Leiden University Medical Centre, Leiden, Netherlands.
Gabri van der PluijmDepartment of Urology, Leiden University Medical Centre, Leiden, Netherlands.
Martin SpahnDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
George N ThalmannDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Peter Ten DijkeDepartment of Molecular Cell Biology, Cancer Genomics Center, Leiden University Medical Centre, Leiden, Netherlands.
Marianna Kruithof-de JulioDepartment of Urology and Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
University of Bern · CHLeiden University · NLCancer Genomics Centre · NLSalk Institute for Biological Studies · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is the second most common cancer in men and lethality is normally associated with the consequences of metastasis rather than the primary tumor. Therefore, targeting the molecular pathways that underlie dissemination of primary tumor cells and the formation of metastases has a great clinical value. Bone morphogenetic proteins (BMPs) play a critical role in tumor progression and this study focuses on the role of BMP9-

Indexed as

ALK1ALK1FcALK2BMP9NOTCHprostate cancer

Identifiers

PMID29259971
PMCPMC5723291
OpenAlexW2775262991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.