Evidence map›Paper›PMID 29259904›Full record

ArticleInternational journal of ophthalmology2017

A new strategy to interpret OCT posterior pole asymmetry analysis for glaucoma diagnosis.

Yi Zhang, Ni Li, Jun Chen, Hong Wei, Shan-Ming Jiang, Xiao-Min Chen

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Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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6 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Yi ZhangWest China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China.
Ni LiDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Jun ChenDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Hong WeiDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Shan-Ming JiangDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Xiao-Min ChenDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo detect early glaucoma by optical coherence tomography (OCT) posterior pole asymmetry analysis.

methodsTotally 39 eyes from 39 healthy subjects, 40 eyes from 40 mild glaucoma patients, 33 eyes from 33 moderate glaucoma patients and 41 eyes from severe glaucoma patients were included in this study. All subjects underwent posterior pole asymmetry analysis (PPAA) of OCT and the posterior pole area was divided into three zones. Means, standard deviations and 95% confidence intervals of each zone asymmetry in control group were assessed. Retina thickness asymmetry (RTA) of different stage of glaucoma were compared for each zone, and receiver operating characteristic (ROC) curves were made to test the efficacy of strategies using different zones to discriminate glaucomatous eyes from the healthy ones.

resultsIn a healthy population, RTA of the centre zone showed the minimal mean value (3.085 µm), standard deviation (1.756), and the narrowest 95% confidence interval (from 2.360 to 3.810 µm). It was only in the center zone that RTA exhibited significant difference between control and moderate glaucoma group (

conclusionUtilizing the posterior pole centre zone to interpret OCT PPAA results are more effective than making use of the whole posterior pole map.

Indexed as

diagnosisglaucomaoptical coherence tomographyposterior pole asymmetry analysis

Identifiers

PMID29259904
PMCPMC5733513

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