Evidence map›Paper›PMID 29259895›Full record

ArticleInternational journal of ophthalmology2017

Age-related changes of corneal endothelial cell in healthy Chinese tree shrew measured by non-contact specular microscope.

Min Wu, De-Xuan Kuang, Ya-Qi Huang, Yu-Run Miao, Xiao-Cheng Liu, Jie-Jie Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Min WuDepartment of Ophthalmology; Yunnan Key Laboratory for prevention and treatment of eye diseases Yunnan Innovation Team for Cataract and Ocular fundus Disease (2017HC010); Yunnan Eye Institute, the 2nd People's Hospital of Yunnan Province (Yunnan Eye Hospital, the 4th Affiliated Hospital of Kunming Medical University), Kunming 650021, Yunnan Province, China.
De-Xuan KuangCenter of Tree Shrew Germplasm Resources; Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases; Yunnan Innovation Team of Standardization and Application Research in Tree Shrew, Kunming 650118, Yunnan Province, China.
Ya-Qi HuangDepartment of Ophthalmology; Yunnan Key Laboratory for prevention and treatment of eye diseases Yunnan Innovation Team for Cataract and Ocular fundus Disease (2017HC010); Yunnan Eye Institute, the 2nd People's Hospital of Yunnan Province (Yunnan Eye Hospital, the 4th Affiliated Hospital of Kunming Medical University), Kunming 650021, Yunnan Province, China.
Yu-Run MiaoCenter of Tree Shrew Germplasm Resources; Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases; Yunnan Innovation Team of Standardization and Application Research in Tree Shrew, Kunming 650118, Yunnan Province, China.
Xiao-Cheng LiuDepartment of Ophthalmology; Yunnan Key Laboratory for prevention and treatment of eye diseases Yunnan Innovation Team for Cataract and Ocular fundus Disease (2017HC010); Yunnan Eye Institute, the 2nd People's Hospital of Yunnan Province (Yunnan Eye Hospital, the 4th Affiliated Hospital of Kunming Medical University), Kunming 650021, Yunnan Province, China.
Jie-Jie DaiCenter of Tree Shrew Germplasm Resources; Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases; Yunnan Innovation Team of Standardization and Application Research in Tree Shrew, Kunming 650118, Yunnan Province, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the impact of age on the morphology of endothelial cells and central corneal thickness (CCT) in Chinese tree shrew.

methodsOne-hundred and twenty eyes of 60 healthy Chinese tree shrews were studied. Based on age, the tree shrews were divided into four groups. After general anesthesia, the images of endothelium were acquired using non-contact specular microscope Topcon 3000P. Eight parameters of corneal endothelial cells were measured by built-in software, including CCT, endothelial cell density (ECD), percent hexagonality (HG%), coefficient of variability (CV), size of minimal cell (Smin), size of maximal cell (Smax), average cells size (Savg) and size standard deviation (Ssd). Data were analyzed using STATA software. The differences of eight parameters among groups and correlations with age were analyzed.

resultsIn all studied animals, the average CCT was 249.6±20.29 µm (202-301 µm), ECD was 3080.72± 460.76 cells/mm

conclusionCornea of Chinese tree shrews had half CCT of human cornea and similar ECD, CV and size of corneal endothelial cells. Young adult tree shrews had higher ECD, HG% and low CV. ECD, Smax, Savg, Ssd and CV correlated with age significantly.

Indexed as

ageChinese tree shrew (Tupaia belangeri chinensis)corneaendothelial cellsspecular microscope

Identifiers

PMID29259895
PMCPMC5733504
OpenAlexW2785284111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.