ArticleIntractable & rare diseases research2017
Estradiol and proinflammatory cytokines stimulate ISG20 expression in synovial fibroblasts of patients with osteoarthritis.
Article in Intractable & rare diseases research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus.Frontiers in immunology · 2024Article
- Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks.Open medicine (Warsaw, Poland) · 2023Article
- Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis.Bioengineered · 2021Article
- High expression of ISG20 predicts a poor prognosis in acute myeloid leukemia.Cancer biomarkers : section A of Disease markers · 2021Article
- ISG20 serves as a potential biomarker and drives tumor progression in clear cell renal cell carcinoma.Aging · 2020Article
- Proteoglycans isolated from the bramble shark cartilage show potential anti-osteoarthritic properties.Inflammopharmacology · 2019Article
- The guiding role of bone metabolism test in osteoporosis treatment.American journal of clinical and experimental immunology · 2018Review
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon stimulated gene 20-kDa (ISG20) has been implicated in the pathology of osteoarthritis (OA) and it has been separately found to be responsive to estrogen stimulation. OA disproportionately affects women, and especially older women, suggesting some role of reproductive hormones in its pathology. The current study characterized the expression of ISG20 following stimulation with estradiol (E2) and proinflammatory cytokines in OA synovial fibroblasts (OASFs). E2 and the proinflammatory cytokines interleukin-6 (IL-6), lipopolysaccharide (LPS), and tumor necrosis factor α (TNF-α) were used to stimulate OASFs
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