Evidence map›Paper›PMID 29259758›Full record

ArticleACS medicinal chemistry letters2017

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

Dong-Oh Yoon, Xiaodi Zhao, Dohyun Son, Jung Tae Han, Jaesook Yun, Dongyun Shin, Hyun-Ju Park

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dong-Oh YoonSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Xiaodi ZhaoSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Dohyun SonSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Jung Tae HanSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Jaesook YunSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Dongyun ShinCollege of Pharmacy, Gachon University, Incheon 21936, South Korea.
Hyun-Ju ParkSchool of Pharmacy and Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea.
Sungkyunkwan University · KRGachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds,

Identifiers

PMID29259758
PMCPMC5733302
OpenAlexW2770836658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.