ArticleTexas Heart Institute journal2017
Torsades de Pointes after Ondansetron Infusion in 2 Patients.
Article in Texas Heart Institute journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Route-specific adverse effects of ondansetron: an overlooked concern in Asian clinical practice.Annals of medicine and surgery (2012) · 2026Article
- Morbidity and Mortality of Ondansetron in Patients with Non-congenital Long QT Syndrome: A Review Article.Cardiovascular drugs and therapy · 2026Review
- Cardiotoxicity of different 5-HT3 receptor antagonists analyzed using the FAERS database and pharmacokinetic study.Scientific reports · 2025Article
- Review
- Ondansetron-induced cardiac arrest and cardiomyopathy with successful reversal: a case report.AME case reports · 2025Article
- Article
- Single intravenous dose ondansetron induces QT prolongation in adult emergency department patients: a prospective observational study.International journal of emergency medicine · 2024Article
- Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database.Frontiers in pharmacology · 2023Article
- Drug Safety in Episodic Migraine Management in Adults Part 1: Acute Treatments.Current pain and headache reports · 2022Review
- Top 20 drug - drug interactions, polypharmacy and analysis of the nature of risk factors due to QT interval prolonging drug use in elderly psychiatry outpatients.Journal of family medicine and primary care · 2020Article
- Maternal ABVD chemotherapy for Hodgkin lymphoma in a dichorionic diamniotic pregnancy: a case report.BMC pregnancy and childbirth · 2020Article
- Perianesthesia Implications and Considerations for Drug-Induced QT Interval Prolongation.Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2020Article
- Leading 20 drug-drug interactions, polypharmacy, and analysis of the nature of risk factors due to QT interval prolonging drug use and potentially inappropriate psychotropic use in elderly psychiatry outpatients.Therapeutic advances in cardiovascular diseaseArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drugs that prolong the electrocardiographic QT interval increase the risk of ventricular arrhythmias, particularly torsades de pointes. Ondansetron, a 5-hydroxytryptamine type 3 receptor antagonist antiemetic, is one such drug. We present the cases of 2 patients who were given intravenous ondansetron and subsequently developed torsades de pointes. Both had normal QT intervals at baseline but were discovered to have risk factors that predisposed them to drug-induced QT prolongation and ventricular arrhythmias. We briefly review the mechanisms for torsades de pointes caused by QT-prolonging medications, describe characteristics that increase patients' susceptibility to drug-induced QT prolongation, and call attention to the risk of ventricular arrhythmias in patients who are given ondansetron.
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