Evidence map›Paper›PMID 29259398›Full record

ArticleReproductive medicine and biology2015

The relationship between p53 codon 72 genetic polymorphism and sperm parameters. A study of men with varicocele.

V Gentile, M Nicotra, S Minucci, S Ambrosi, P Saccucci, F Gloria-Bottini, E Bottini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The role of p53 in male infertility.Frontiers in endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

V GentileDepartment of Gynaecologic, Obstetric and Urologic Sciences University of Rome La Sapienza Rome Italy.
M NicotraDepartment of Gynaecologic, Obstetric and Urologic Sciences University of Rome La Sapienza Rome Italy.
S MinucciS. Camillo Hospital Rome Italy.
S AmbrosiDepartment of Gynaecologic, Obstetric and Urologic Sciences University of Rome La Sapienza Rome Italy.
P SaccucciDepartment of Biomedicine and Preventio nUniversity of Rome Tor Vergata Via Montpellier, 100133 Rome Italy.
F Gloria-BottiniDepartment of Biomedicine and Preventio nUniversity of Rome Tor Vergata Via Montpellier, 100133 Rome Italy.
E BottiniDepartment of Biomedicine and Preventio nUniversity of Rome Tor Vergata Via Montpellier, 100133 Rome Italy.
Sapienza University of Rome · ITUniversity of Rome Tor Vergata · ITIRCCS San Camillo Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Regulation of the apoptotic process has an important role in spermatogenesis. p53 has a prominent function in apoptosis and recent data suggest a relationship between varicocele and p53 codon 72 polymorphism and male infertility. This prompted us to study the relationship between this polymorphism and spermatic parameters. Methods: We studied 134 subjects with varicocele admitted consecutively to the outpatients Department of Infertility at the University of Rome La Sapienza. We investigated in these subjects the effect of a strong apoptosis inducer, the p53 codon 72 *Arg/*Arg genotype, on spermatic parameters.The p53 codon 72 genotype was determined by DNA analysis. Results: The proportion of spermatozoa with abnormal (curvilinear) motility is higher in men with the *Arg/*Arg genotype than in men carrying the *Pro allele ( Conclusions: We conclude: the p53 codon 72*Arg/*Arg genotype, with its strong apoptotic effects, negatively influences spermatozoa motility and male fertility.

Indexed as

ApoptosisMale fertilityp53 codon 72Sperm parametersVaricocele

Identifiers

PMID29259398
PMCPMC5715821
OpenAlexW2091261373

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.