Evidence map›Paper›PMID 29259391›Full record

ArticleMolecular vision2017

Melatonin partially protects 661W cells from H

Aída Sánchez-Bretaño, Kenkichi Baba, Uzair Janjua, Ilaria Piano, Claudia Gargini, Gianluca Tosini

Open access · greenAbstract read
In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Protective effects ofHistology and histopathology · 2026
    Article
  2. Review
  3. Fucosylated oligosaccharide Lacto-Food chemistry: X · 2022
    Article
  4. Nontraditional Risk Factors for Obesity in Modern Society.Journal of obesity & metabolic syndrome · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Heteromeric MTExperimental eye research · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aída Sánchez-BretañoDepartment of Pharmacology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Kenkichi BabaDepartment of Pharmacology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Uzair JanjuaDepartment of Pharmacology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Ilaria PianoDepartment of Pharmacology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
Claudia GarginiDipartimento di Farmacia, Universita di Pisa, Pisa, Italy.
Gianluca TosiniDepartment of Pharmacology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA.
University of Pisa · IT

Funding

Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
TRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI LIU, DONG · 1986 to 2011
$32.4M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI QUASHIE, ALEXANDER · 2012 to 2018
$24.8M
WARCEFU54RR026137 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI HARRIS-HOOKER, SANDRA · 2009 to 2011
$14.6M
Program Evaluation - Internal & External U54NS083932 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MACLEISH, PETER RAYMOND · 2013 to 2017
$7.7M
Circadian regulation of RPE functionsR01EY026291 · NEI · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2016 to 2020
$2.1M
Photic and Circadian Regulation of Retinal MelatoninR01EY022216 · NEI · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2012 to 2015
$1.4M
NCRR NIH HHS G12 RR003034NCRR NIH HHS U54 RR026137NEI NIH HHS R01 EY022216NEI NIH HHS R01 EY026291NIMHD NIH HHS S21 MD000101NIMHD NIH HHS U54 MD007588NINDS NIH HHS U54 NS083932
6 · The paper itself

Abstract

Purpose: Previous studies have shown that melatonin (MEL) signaling is involved in the modulation of photoreceptor viability during aging. Recent work by our laboratory suggested that MEL may protect cones by modulating the Fas/FasL-caspase-3 pathway. In this study, we first investigated the presence of MEL receptors (MT Methods: The mRNA and proteins of the MEL receptors were detected with quantitative PCR (q-PCR) and immunocytochemistry, respectively. To test the protective effect of MEL, 661W cells were treated with H Results: Both MEL receptors (MT Conclusions: The results demonstrate that MEL receptors are present and functional in 661W cells. MEL can prevent photoreceptor cell death induced by H

Indexed as

AnimalsAntioxidantsCaspase 3Cell LineCell SurvivalDose-Response Relationship, DrugFas Ligand Proteinfas ReceptorHydrogen PeroxideImmunohistochemistryMelatoninMiceMicroscopy, ConfocalOxidantsReal-Time Polymerase Chain ReactionReceptor, Melatonin, MT1AntioxidantsCasp3 protein, mouseCaspase 3Fas Ligand ProteinFasl protein, mousefas ReceptorHydrogen PeroxideMelatoninOxidantsReceptor, Melatonin, MT1Receptor, Melatonin, MT2RNA, Messenger

Identifiers

PMID29259391
PMCPMC5723148
OpenAlexW2775218109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.