Evidence map›Paper›PMID 29259376›Full record

ArticleWorld journal of gastroenterology2017

Albumin as a prognostic marker for ulcerative colitis.

Nabeel Khan, Dhruvan Patel, Yash Shah, Chinmay Trivedi, Yu-Xiao Yang

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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    Article
  19. Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc).Journal of pharmacokinetics and pharmacodynamics · 2024
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nabeel KhanSection of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States.
Dhruvan PatelDepartment of Gastroenterology, Drexel University College of Medicine, Philadelphia, PA 19102, United States.
Yash ShahDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai, James J. Peters VA Medical Center, Bronx, NY 10468, United States.
Chinmay TrivediSection of Gastroenterology, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104, United States.
Yu-Xiao YangSection of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States.
James J. Peters VA Medical Center · USDrexel University · USIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the role of albumin at the time of ulcerative colitis (UC) diagnosis in predicting the clinical course of disease.

methodsNationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia (

resultsThe eligible study cohort included 802 patients, but 92 (11.4%) patients did not have their albumin levels checked at the time of UC diagnosis, and they were excluded. A total of 710 patients, who had albumin levels checked at time of UC diagnosis, were included in our study. Amongst them, 536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of ≥ 2 courses of CS use (adjusted HR = 1.7, 95%CI: 1.3-2.3), higher likelihood of thiopurine or anti- TNF use (adjusted HR = 1.72, 95%CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients, but it was not statistically significant (Adjusted HR = 1.7, 95%CI: 0.90-3.25).

conclusionHypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis.

Indexed as

Adrenal Cortex HormonesAdultAgedBiomarkersColectomyColitis, UlcerativeFemaleFollow-Up StudiesHumansHypoalbuminemiaImmunosuppressive AgentsMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsAdrenal Cortex HormonesBiomarkersImmunosuppressive AgentsSerum AlbuminTumor Necrosis Factor-alphaAlbuminColectomyDisease coursePrognostic markerUlcerative colitis

Identifiers

PMID29259376
PMCPMC5725295
OpenAlexW2772946125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.