ArticleWorld journal of gastroenterology2017
Improved experimental model of hepatic cystic hydatid disease resembling natural infection route with stable growing dynamics and immune reaction.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cattle as Biological Indicators ofAnimals : an open access journal from MDPI · 2026Article
- A novel method for establishing a mouse model of hepatic echinococcosis: Ultrasound-guided percutaneous liver puncture modeling.PLoS neglected tropical diseases · 2026Article
- Historical changes in surgical strategy and complication management for hepatic cystic echinococcosis.World journal of gastrointestinal surgery · 2023Review
- Establishment of a secondary infection laboratory model ofParasitology · 2023Article
- Article
- The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.PLoS neglected tropical diseases · 2021Article
- Development of an improved anesthesia protocol to increase CF1 mice survival in a portal vein infection withHeliyon · 2021Article
- Metabolomics Analysis of Splenic CD19Frontiers in veterinary science · 2021Article
- The local immune response during Echinococcus granulosus growth in a quantitative hepatic experimental model.Scientific reports · 2019Article
- Bone marrow-derived mesenchymal stem cell (BM-MSC): A tool of cell therapy in hydatid experimentally infected rats.Cell regeneration (London, England) · 2019Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate a safer way to set up the disease model of cystic echinococcosis without contamination risk and develop a novel experimental murine model of hepatic cystic echinococcosis.
methodsC57B/6 mice were injected with human protoscolices of three different concentrations
resultsThe infection rates in the mice in the high, medium, and low concentration groups were 90%, 100%, and 63.6%, respectively. The protoscolices migrated in the portal vein with blood flow, settled in the liver, and developed into orthotopic hepatic hydatid cysts, resembling the natural infection route and course.
conclusionWe have established an improved experimental model of hepatic cystic echinococcosis with low biohazard risk but stable growing dynamics and immune reaction. It is especially useful for new anti-parasite medication trials against hydatid disease.
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