ArticleScientific reports2017
Revisiting medial preoptic area plasticity induced in male mice by sexual experience.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Central SELENOT deficiency impairs gonadotrope axis function, sexual behavior, and fertility in male and female mice.JCI insight · 2025Article
- Opposite sex housing enhances reproductive function and induces transcriptional changes in the preoptic area of GnRH-deficient mice.Frontiers in endocrinology · 2025Article
- Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture.Environmental health perspectives · 2023Article
- Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS.Frontiers in endocrinology · 2023Article
- Mating experiences with the same partner enhanced mating activities of naïve male medaka fish.Scientific reports · 2022Article
- Effects of early life adversity on male reproductive behavior and the medial preoptic area transcriptome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Flexibility of neural circuits regulating mating behaviors in mice and flies.Frontiers in neural circuits · 2022Review
- Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System.Biomolecules · 2021Review
- Sexual Experience Induces the Expression of Gastrin-Releasing Peptide and Oxytocin Receptors in the Spinal Ejaculation Generator in Rats.International journal of molecular sciences · 2021Article
- Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior.Frontiers in neuroscience · 2021Review
- Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence.Frontiers in behavioral neuroscience · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA), the main integrative structure for male sexual behaviour, after a single mating event. This paradigm induced long-lasting behavioural improvements and mPOA morphological changes, evidenced by dendritic spine maturation and an increase in the acetylated and tri-methylated forms of histone H3. Ejaculation affected testosterone, progesterone and corticosterone levels in both naive and experienced mice, but sexual experience did not modify basal plasma or hypothalamic levels of steroids. In contrast to studies carried out in rats, no changes were observed, either in the nitrergic system, or in sex steroid receptor levels. However, levels of glutamate- and calcium-associated proteins, including PSD-95, calbindin and the GluN1 subunit of the NMDA receptor, were increased in sexually experienced male mice. The Iba-1 microglial marker was up-regulated in these animals suggesting multicellular interactions induced within the mPOA by sexual experience. In conclusion, plasticity mechanisms induced by sexual experience differ between rat and mouse, even if in both cases they converge to potentiation of the mPOA network.
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