Evidence map›Paper›PMID 29259302›Full record

ArticleScientific reports2017

Modelling neuroanatomical variation during childhood and adolescence with neighbourhood-preserving embedding.

Gareth Ball, Chris Adamson, Richard Beare, Marc L Seal

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. BrainAGE as a measure of maturation during early adolescence.Imaging neuroscience (Cambridge, Mass.) · 2023
    Article
  10. Article
  11. Accelerated brain aging predicts impulsivity and symptom severity in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  12. Multimodal Sparse Classifier for Adolescent Brain Age Prediction.IEEE journal of biomedical and health informatics · 2020
    Article
  13. Article
  14. Review
  15. [A review on brain age prediction in brain ageing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gareth BallDevelopmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia. gareth.ball@mcri.edu.au.ORCID 0000-0003-3509-1435
Chris AdamsonDevelopmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia.
Richard BeareDevelopmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia.
Marc L SealDevelopmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia.ORCID 0000-0002-8396-140X

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
NIDA NIH HHS RC2 DA029475
6 · The paper itself

Abstract

Brain development is a dynamic process with tissue-specific alterations that reflect complex and ongoing biological processes taking place during childhood and adolescence. Accurate identification and modelling of these anatomical processes in vivo with MRI may provide clinically useful imaging markers of individual variability in development. In this study, we use manifold learning to build a model of age- and sex-related anatomical variation using multiple magnetic resonance imaging metrics. Using publicly available data from a large paediatric cohort (n = 768), we apply a multi-metric machine learning approach combining measures of tissue volume, cortical area and cortical thickness into a low-dimensional data representation. We find that neuroanatomical variation due to age and sex can be captured by two orthogonal patterns of brain development and we use this model to simultaneously predict age with a mean error of 1.5-1.6 years and sex with an accuracy of 81%. We validate this model in an independent developmental cohort. We present a framework for modelling anatomical development during childhood using manifold embedding. This model accurately predicts age and sex based on image-derived markers of cerebral morphology and generalises well to independent populations.

Indexed as

AdolescentAdultCerebral CortexChildChild, PreschoolCohort StudiesFemaleHumansMachine LearningMagnetic Resonance ImagingMaleYoung Adult

Identifiers

PMID29259302
PMCPMC5736651

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.