Evidence map›Paper›PMID 29259282›Full record

ArticleScientific reports2017

Analysis of killing of growing cells and dormant and germinated spores of Bacillus species by black silicon nanopillars.

Sonali Ghosh, Shanyuan Niu, Maya Yankova, Matthew Mecklenburg, Stephen M King, Jayakanth Ravichandran, Rajiv K Kalia, Aiichiro Nakano, Priya Vashishta, Peter Setlow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. What's new and notable in bacterial spore killing!World journal of microbiology & biotechnology · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sonali GhoshDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT, 06030-3305, USA.
Shanyuan NiuDepartment of Chemical Engineering and Material Science, University of Southern California, Los Angeles, CA, 90089-0241, USA.
Maya YankovaCentral Electron Microscopy Facility, UConn Health, Farmington, CT, 06030-1610, USA.
Matthew MecklenburgCenter for Electron Microscopy and Microanalysis, University of Southern California, Los Angeles, CA, 90089-0101, USA.
Stephen M KingDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT, 06030-3305, USA.
Jayakanth RavichandranDepartment of Chemical Engineering and Material Science, University of Southern California, Los Angeles, CA, 90089-0241, USA.
Rajiv K KaliaCollaboratory for Advanced Computing and Simulations and Department of Chemical Engineering and Material Science, University of Southern California, Los Angeles, CA, 90089-0242, USA.
Aiichiro NakanoCollaboratory for Advanced Computing and Simulations and Department of Chemical Engineering and Material Science, University of Southern California, Los Angeles, CA, 90089-0242, USA.
Priya VashishtaCollaboratory for Advanced Computing and Simulations and Department of Chemical Engineering and Material Science, University of Southern California, Los Angeles, CA, 90089-0242, USA. priyav@usc.edu.
Peter SetlowDepartment of Molecular Biology and Biophysics, UConn Health, Farmington, CT, 06030-3305, USA. setlow@uchc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Black silicon (bSi) wafers with a high density of high-aspect ratio nanopillars have recently been suggested to have mechanical bactericidal activity. However, it remains unclear whether bSi with the nanopillars can kill only growing bacterial cells or also dormant spores that are harder to kill. We have reexamined the cidal activity of bSi on growing cells, dormant and germinated spores of B. subtilis, and dormant spores of several other Bacillus species by incubation on bSi wafers with and without nanopillars. We found that the bSi wafers with nanopillars were indeed very effective in rupturing and killing the growing bacterial cells, while wafers without nanopillars had no bactericidal effect. However, bSi wafers with or without nanopillars gave no killing or rupture of dormant spores of B. subtilis, Bacillus cereus or Bacillus megaterium, although germinated B. subtilis spores were rapidly killed. This work lays a foundation for novel bactericidal applications of bSi by elucidating the limits of mechanical bactericidal approaches.

Identifiers

PMID29259282
PMCPMC5736721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.