Evidence map›Paper›PMID 29259134›Full record

ArticleThe Journal of biological chemistry2018

Computational antimicrobial peptide design and evaluation against multidrug-resistant clinical isolates of bacteria.

Deepesh Nagarajan, Tushar Nagarajan, Natasha Roy, Omkar Kulkarni, Sathyabaarathi Ravichandran, Madhulika Mishra, Dipshikha Chakravortty, Nagasuma Chandra

Abstract readValidation Study
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Discovery of a Novel Antimicrobial Peptide fromAntibiotics (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. FDA-Approved Antibacterials and Echinocandins.Antibiotics (Basel, Switzerland) · 2025
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deepesh NagarajanFrom the Departments of Biochemistry and.
Tushar NagarajanComputational and Data Sciences.
Natasha RoyMolecular Biophysics Unit.
Omkar KulkarniFrom the Departments of Biochemistry and.
Sathyabaarathi RavichandranFrom the Departments of Biochemistry and.
Madhulika MishraFrom the Departments of Biochemistry and.
Dipshikha ChakravorttyDepartment of Microbiology and Cell Biology, and.
Nagasuma ChandraFrom the Departments of Biochemistry and nchandra@iisc.ac.in sumachandra@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a pressing need for new therapeutics to combat multidrug- and carbapenem-resistant bacterial pathogens. This challenge prompted us to use a long short-term memory (LSTM) language model to understand the underlying grammar,

Indexed as

Drug DesignDrug Resistance, Multiple, BacterialProtein EngineeringAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCarbapenem-Resistant EnterobacteriaceaeCell LineCell MembraneComputational BiologyEnterobacteriaceae InfectionsFemaleGene Expression Regulation, BacterialHumansMachine LearningMaleAnti-Bacterial AgentsAntimicrobial Cationic PeptidesRecombinant Proteinsantibiotic resistanceantimicrobial peptide (AMP)computational biologydrug designdrug resistanceLSTM

Identifiers

PMID29259134
PMCPMC5846155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.