ArticleProceedings of the National Academy of Sciences of the United States of America2018
Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Dissecting planar and vertical organiser signals in early chick neural development.Development (Cambridge, England) · 2026Article
- Molecular basis of competence for neural induction in the chick embryo.bioRxiv : the preprint server for biology · 2026Article
- Association Between Head Circumference Growth and Peripheral Nerve Cross-Sectional Area Growth in Infants: A Potential Future Biomarker for Central and Peripheral Nerve Maturation.Neuropediatrics · 2026Article
- Cell biology of the chick organizer: Origins, composition, population dynamics and fate.Cells & development · 2025Review
- The organizer as a cooperative of signaling cells for neural induction.bioRxiv : the preprint server for biology · 2025Article
- The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Article
- A gene regulatory network for neural induction.eLife · 2023Article
- Review
- Tissue Rotation of theJournal of developmental biology · 2022Article
- Folate Carrier Deficiency Drives Differential Methylation and Enhanced Cellular Potency in the Neural Plate Border.Frontiers in cell and developmental biology · 2022Article
- Repressive Interactions Between Transcription Factors Separate Different Embryonic Ectodermal Domains.Frontiers in cell and developmental biology · 2022Article
- Article
- Blastula stage specification of avian neural crest.Developmental biology · 2020Article
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border.Frontiers in physiology · 2020Review
- PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.Development (Cambridge, England) · 2019Article
- Znf703 is a novel RA target in the neural plate border.Scientific reports · 2019Article
- Six1 and Irx1 have reciprocal interactions during cranial placode and otic vesicle formation.Developmental biology · 2019Article
- Specification and formation of the neural crest: Perspectives on lineage segregation.Genesis (New York, N.Y. : 2000) · 2019Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually express lens markers. We designate this state as "preborder"; its transcriptome resembles embryonic stem cells. Finally, using sequential transplantation experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these inductions while the final outcome depends on the tissue emitting the later signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.